6KNU

THRb mutation with a novel agonist

Summary for 6KNU

• Entry DOI: 10.2210/pdb6knu/pdb
• Related: 6KKB
• Descriptor: Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, ... (4 entities in total)
• Functional Keywords: agonist, thyroid hormone receptor, anemia, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 29989.67

Authors

Yao, B.Q.,Li, Y. (deposition date: 2019-08-07, release date: 2019-10-23, Last modification date: 2023-11-22)

• Primary citation: Yao, B.,Wei, Y.,Zhang, S.,Tian, S.,Xu, S.,Wang, R.,Zheng, W.,Li, Y.; Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance.; Iscience, 20:489-496, 2019; PubMed: 31655060; DOI: 10.1016/j.isci.2019.10.002

Experimental method

X-RAY DIFFRACTION (2.7 Å)