PDB: 539 件ウェブページステータス検索Chemie searchBIRD

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5WAT	Corynebacterium glutamicum Full length Homoserine kinase 分子名称: HEXAETHYLENE GLYCOL, Homoserine kinase, MAGNESIUM ION, ... 著者 Petit, C, Ronning, D.R. 登録日 2017-06-27 公開日 2018-02-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.141 Å) 主引用文献 Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
5WAS	Corynebacterium glutamicum Hydrolyzed Homoserine kinase 分子名称: Homoserine kinase, PHOSPHATE ION 著者 Petit, C, Ronning, D.R. 登録日 2017-06-27 公開日 2018-02-07 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
6CYZ	Mycobacterial homoserine kinase ThrB in complex with AMPPNP 分子名称: CHLORIDE ION, Homoserine kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Li, J, Korotkov, K.V. 登録日 2018-04-07 公開日 2018-04-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Mycobacterial homoserine kinase ThrB To Be Published
3HUL	Structure of putative homoserine kinase thrB from Listeria monocytogenes 分子名称: Homoserine kinase, SULFATE ION 著者 Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2009-06-15 公開日 2009-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Structure of putative homoserine kinase thrB from Listeria monocytogenes To be published
6KNW	THRb mutation with a novel agonist 分子名称: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta 著者 Yao, B.Q, Li, Y. 登録日 2019-08-07 公開日 2019-10-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
6KNV	THRb mutation with a novel agonist 分子名称: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta 著者 Yao, B.Q, Li, Y. 登録日 2019-08-07 公開日 2019-10-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
6KKE	THRb mutation with a novel agonist 分子名称: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, SRC2-3, Thyroid hormone receptor beta 著者 Yao, B.Q, Li, Y. 登録日 2019-07-25 公開日 2019-10-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.577 Å) 主引用文献 Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
6KNU	THRb mutation with a novel agonist 分子名称: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, Nuclear receptor coactivator 2, Thyroid hormone receptor beta 著者 Yao, B.Q, Li, Y. 登録日 2019-08-07 公開日 2019-10-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
5NHU	HUMAN ALPHA THROMBIN COMPLEXED WITH ANOPHELES GAMBIAE cE5 ANTICOAGULANT 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AGAP008004-PA, Prothrombin, ... 著者 Ripoll-Rozada, J, Pereira, P.J.B. 登録日 2017-03-22 公開日 2017-06-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae. J. Biol. Chem., 292, 2017
7PHX	Tsetse thrombin inhibitor in complex with human alpha-thrombin - acid-stable sulfotyrosine analogue 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Thrombin heavy chain, ... 著者 Pereira, P.J.B, Ripoll-Rozada, J, Calisto, B.M. 登録日 2021-08-18 公開日 2021-10-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogues. Chem.Commun.(Camb.), 57, 2021
7SR9	Human alpha-thrombin with 180- and 220- loops replaced with homologous loops from protein C 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... 著者 Di Cera, E, Ruben, E.A, Chen, Z. 登録日 2021-11-08 公開日 2021-12-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The active site region plays a critical role in Na + binding to thrombin. J.Biol.Chem., 298, 2022
8KME	CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN INHIBITED WITH SEL2770. 分子名称: N-ACETYLHIRUDIN, SEL2770, SODIUM ION, ... 著者 Mochalkin, I, Tulinsky, A. 登録日 1999-03-21 公開日 1999-03-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding. Acta Crystallogr.,Sect.D, 55, 1999
6KKB	A novel agonist of THRb 分子名称: 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid, SRC2-3, Thyroid hormone receptor beta 著者 Yao, B.Q, Li, Y. 登録日 2019-07-24 公開日 2019-10-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Revealing a Mutant-Induced Receptor Allosteric Mechanism for the Thyroid Hormone Resistance. Iscience, 20, 2019
7WMJ	A novel chemical derivative(71) of THRB agonist 分子名称: 2-[[7-[2,6-dimethyl-4-(phenylcarbonyl)phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 著者 Yao, B.Q, Li, Y. 登録日 2022-01-14 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WLX	A novel chemical derivative(53) of THRB agonist 分子名称: 2-[[1-methoxy-4-oxidanyl-7-[4-(phenylmethyl)phenoxy]isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 著者 Yao, B.Q, Li, Y. 登録日 2022-01-14 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMO	A novel chemical derivative(92) of THRB agonist 分子名称: 2-[[1-ethoxy-7-[4-(3-fluoranyl-5-methoxy-phenyl)carbonyl-2,6-dimethyl-phenoxy]-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 著者 Yao, B.Q, Li, Y. 登録日 2022-01-15 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMG	A novel chemical derivative(52) of THRB agonist 分子名称: 2-[[1-methoxy-4-oxidanyl-7-(4-phenoxyphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 著者 Yao, B.Q, Li, Y. 登録日 2022-01-14 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMN	A novel chemical derivative(89) of THRB agonist 分子名称: 2-[[7-[2,6-dimethyl-4-(3-methylphenyl)carbonyl-phenoxy]-1-methoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 著者 Yao, B.Q, Li, Y. 登録日 2022-01-15 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WML	A novel chemical derivative(85) of THRB agonist 分子名称: 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 著者 Yao, B.Q, Li, Y. 登録日 2022-01-15 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
7WMH	A novel chemical derivative(56) of THRB agonist 分子名称: 2-[[1-methoxy-4-oxidanyl-7-(4-phenylphenoxy)isoquinolin-3-yl]carbonylamino]ethanoic acid, Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2 著者 Yao, B.Q, Li, Y. 登録日 2022-01-14 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65, 2022
8TQS	Complex of human thrombin (S195A) bound to a bivalent inhibitor comprised of DNA Aptamer HD22 conjugated to Dabigatran with a linker. 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (30-MER), ... 著者 Krishnaswamy, S, Kumar, S. 登録日 2023-08-08 公開日 2024-05-01 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.207 Å) 主引用文献 Aptameric hirudins as selective and reversible EXosite-ACTive site (EXACT) inhibitors. Nat Commun, 15, 2024
8UF7	Cryo-EM structure of POmAb, a Type-I anti-prothrombin antiphospholipid antibody, bound to kringle-1 of human prothrombin 分子名称: POmAb Heavy Chain, POmAb Light Chain, Prothrombin 著者 Kumar, S, Summers, B, Basore, K, Pozzi, N. 登録日 2023-10-03 公開日 2024-02-14 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structure and functional basis of prothrombin recognition by a type I antiprothrombin antiphospholipid antibody. Blood, 143, 2024
4YES	Thrombin in complex with (S)-(4-chloro-2-((1-(5-methyl-1H-pyrrole-2-carbonyl)pyrrolidine-2-carboxamido)methyl)phenyl)methanaminium 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hirudin, ... 著者 Orth, P. 登録日 2015-02-24 公開日 2015-06-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement. Acs Med.Chem.Lett., 6, 2015
2HPP	Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human ppack-thrombin 分子名称: ALPHA-THROMBIN HEAVY CHAIN, ALPHA-THROMBIN LIGHT CHAIN, D-phenylalanyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-L-prolinamide, ... 著者 Tulinsky, A, Padmanabhan, K. 登録日 1993-04-28 公開日 1994-01-31 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin. Biochemistry, 32, 1993
2SPT	DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTHROMBIN, STRONTIUM ION 著者 Tulinsky, A. 登録日 1994-02-01 公開日 1994-05-31 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Differences in the metal ion structure between Sr- and Ca-prothrombin fragment 1. Biochemistry, 33, 1994

 

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