PDB: 1932 件ウェブページステータス検索Chemie searchBIRD

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4OOW	HCV NS5B polymerase with a fragment of quercetagetin 分子名称: CATECHOL, RNA-directed RNA polymerase 著者 Guichou, J.F, Ahmed-Belkacem, A, Rozenn, B, Nazim, N, Hernandez, E, Pallier, C, Pawlotsky, J.M. 登録日 2014-02-04 公開日 2014-12-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res., 42, 2014
3VQS	Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor 分子名称: (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide, CHLORIDE ION, RNA-directed RNA polymerase 著者 Adachi, T, Doi, S, Ando, I, Sugimoto, K, Orita, T, Nomura, A, Kamada, M. 登録日 2012-03-30 公開日 2012-08-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. Antimicrob.Agents Chemother., 56, 2012
1TQL	POLIOVIRUS POLYMERASE G1A MUTANT 分子名称: ACETIC ACID, RNA-directed RNA polymerase 著者 Thompson, A.A, Peersen, O.B. 登録日 2004-06-17 公開日 2004-08-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase Embo J., 23, 2004
8GY6	Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding 分子名称: Gossypol, Non-structural protein 7, Non-structural protein 8, ... 著者 Wang, W, Ren, M, Li, F. 登録日 2022-09-21 公開日 2023-11-01 実験手法 ELECTRON MICROSCOPY 主引用文献 Structure of SARS-CoV-2 RNA-dependent RNA polymerase with gossypol binding To Be Published
6LD2	Zika NS5 polymerase domain 分子名称: (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD1	Zika NS5 polymerase domain 分子名称: 1,2-ETHANEDIOL, RNA-directed RNA polymerase NS5, ZINC ION 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD5	Zika NS5 polymerase domain 分子名称: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD4	Zika NS5 polymerase domain 分子名称: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, 3-methoxybenzenesulfonamide, RNA-directed RNA polymerase NS5, ... 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD3	Zika NS5 polymerase domain 分子名称: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
4IEG	Structure and interactions of the RNA-dependent RNA polymerase from bacteriophage phi12 (P1 crystal form) 分子名称: MAGNESIUM ION, RNA-dependent RNA polymerase P2 著者 Ren, Z, Franklin, M.C, Ghose, R. 登録日 2012-12-13 公開日 2013-07-24 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the RNA-directed RNA Polymerase from the cystovirus 12. Proteins, 81, 2013
1QUV	CRYSTAL STRUCTURE OF THE RNA DIRECTED RNA POLYMERASE OF HEPATITIS C VIRUS 分子名称: PROTEIN (RNA-DIRECTED RNA POLYMERASE) 著者 Ago, H, Miyano, M, Adachi, T, Habuka, N. 登録日 1999-07-04 公開日 1999-11-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure Fold.Des., 7, 1999
5HN0	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 分子名称: (6-hydroxybiphenyl-3-yl)acetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
5HMX	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10 分子名称: 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
5HMY	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 分子名称: 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
5HMZ	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23 分子名称: 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
5HMW	Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 5 分子名称: 2,2'-biphenyl-3,5-diyldiacetic acid, RNA-directed RNA polymerase NS5, ZINC ION 著者 Noble, C.G. 登録日 2016-01-17 公開日 2016-03-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59, 2016
1YV2	Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a 分子名称: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION 著者 Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G. 登録日 2005-02-14 公開日 2005-03-22 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors J.Biol.Chem., 280, 2005
4KHR	HCV NS5B GT1A C316Y with GSK5852 分子名称: NS5B RNA-dependent RNA polymerase, SULFATE ION, [4-({[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl](methylsulfonyl)amino}methyl)-2-fluorophenyl]boronic acid 著者 Williams, S.P, Kahler, K.M, Shotwell, J.B. 登録日 2013-05-01 公開日 2013-05-29 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase. J.Med.Chem., 57, 2014
1WAC	Back-priming mode of Phi6 RNA-dependent RNA polymerase 分子名称: P2 PROTEIN 著者 Laurila, M.R.L, Salgado, P.S, Stuart, D.I, Grimes, J.M, Bamford, D.H. 登録日 2004-10-26 公開日 2005-01-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Back-Priming Mode of Phi6 RNA-Dependent RNA Polymerase J.Gen.Virol., 86, 2005
2E9R	Foot-and-mouth disease virus RNA-dependent RNA polymerase in complex with a template-primer RNA and with ribavirin 分子名称: 5'-R(*CP*AP*UP*GP*GP*GP*CP*CP*C)-3', 5'-R(*CP*CP*C*GP*GP*GP*CP*CP*C)-3', MAGNESIUM ION, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2007-01-26 公開日 2007-06-26 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Sequential structures provide insights into the fidelity of RNA replication Proc.Natl.Acad.Sci.Usa, 104, 2007
2F8E	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein 分子名称: MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... 著者 Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. 登録日 2005-12-02 公開日 2006-03-28 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
8IIB	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta85 mutant (residues 86-546) 分子名称: CADMIUM ION, CHLORIDE ION, MAGNESIUM ION, ... 著者 Fang, X, Lu, G, Hou, C, Gong, P. 登録日 2023-02-24 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
8IIC	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta40 mutant (residues 41-546) 分子名称: Polymerase polyprotein 著者 Fang, X, Lu, G, Hou, C, Gong, P. 登録日 2023-02-24 公開日 2023-06-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
7EEI	Structure of Rift Valley fever virus RNA-dependent RNA polymerase 分子名称: Replicase 著者 Wang, X, Hu, C.X. 登録日 2021-03-18 公開日 2021-11-17 最終更新日 2022-03-16 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure of Rift Valley Fever Virus RNA-Dependent RNA Polymerase. J.Virol., 96, 2022
3VWS	Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107 分子名称: 5-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-1-benzofuran-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, Non-structural protein 5, ... 著者 Noble, C.G, Lescar, J. 登録日 2012-08-31 公開日 2013-02-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor J.Virol., 87, 2013

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