3VQS

Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor

Summary for 3VQS

Entry DOI	10.2210/pdb3vqs/pdb
Related	1QUV 2DXS
Descriptor	RNA-directed RNA polymerase, (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	rna-dependent rna polymerase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Hepatitis C virus
Total number of polymer chains	4
Total formula weight	259879.85
Authors	Adachi, T.,Doi, S.,Ando, I.,Sugimoto, K.,Orita, T.,Nomura, A.,Kamada, M. (deposition date: 2012-03-30, release date: 2012-08-08)
Primary citation	Ando, I.,Adachi, T.,Ogura, N.,Toyonaga, Y.,Sugimoto, K.,Abe, H.,Kamada, M.,Noguchi, T. Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase. Antimicrob.Agents Chemother., 56:4250-4256, 2012 Cited by PubMed: 22615294 DOI: 10.1128/AAC.00312-12 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation