5HMZ

Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23

Summary for 5HMZ

Entry DOI	10.2210/pdb5hmz/pdb
Related	5HMW 5HMX 5HMY 5HN0
Descriptor	RNA-directed RNA polymerase NS5, ZINC ION, 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide, ... (4 entities in total)
Functional Keywords	inhibitor complex polymerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Dengue virus 3
Total number of polymer chains	1
Total formula weight	74135.14
Authors	Noble, C.G. (deposition date: 2016-01-17, release date: 2016-03-30, Last modification date: 2023-11-08)
Primary citation	Yokokawa, F.,Nilar, S.,Noble, C.G.,Lim, S.P.,Rao, R.,Tania, S.,Wang, G.,Lee, G.,Hunziker, J.,Karuna, R.,Manjunatha, U.,Shi, P.Y.,Smith, P.W. Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59:3935-3952, 2016 Cited by PubMed: 26984786 DOI: 10.1021/acs.jmedchem.6b00143 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation