4OOW

HCV NS5B polymerase with a fragment of quercetagetin

Summary for 4OOW

• Entry DOI: 10.2210/pdb4oow/pdb
• Descriptor: RNA-directed RNA polymerase, CATECHOL (3 entities in total)
• Functional Keywords: enzyme, transferase
• Biological source: Hepatitis C virus (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• Total number of polymer chains: 2
• Total formula weight: 129165.93

Authors

Guichou, J.F.,Ahmed-Belkacem, A.,Rozenn, B.,Nazim, N.,Hernandez, E.,Pallier, C.,Pawlotsky, J.M. (deposition date: 2014-02-04, release date: 2014-12-17, Last modification date: 2023-09-20)

• Primary citation: Ahmed-Belkacem, A.,Guichou, J.F.,Brillet, R.,Ahnou, N.,Hernandez, E.,Pallier, C.,Pawlotsky, J.M.; Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention.; Nucleic Acids Res., 42:9399-9409, 2014; PubMed: 25053847; DOI: 10.1093/nar/gku632

Experimental method

X-RAY DIFFRACTION (2.57 Å)