PDB: 118 resultsInfo pagesStatus searchChemie searchBIRD

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7ZGJ	Trypanosoma brucei gambiense ISG65 in complex with human complement component C3 Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3, ... Authors: Suelzen, H, Zoll, S. Deposit date: 2022-04-03 Release date: 2023-04-05 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. Nat Commun, 14, 2023
7ZGK	Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3 beta chain, ... Authors: Suelzen, H, Zoll, S. Deposit date: 2022-04-03 Release date: 2023-04-05 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.59 Å) Cite: Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction. Nat Commun, 14, 2023
8AYH	Structure of Complement C5 in Complex with small molecule inhibitor and CVF Descriptor: 5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid, Cobra venom factor, Complement C5 alpha chain, ... Authors: Srinivas, H. Deposit date: 2022-09-02 Release date: 2022-12-21 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: A small-molecule inhibitor of C5 complement protein. Nat.Chem.Biol., 15, 2019
8B0H	2C9, C5b9-CD59 cryoEM structure Descriptor: CD59 glycoprotein, Complement C5, Complement component C6, ... Authors: Couves, E.C, Gardner, S, Bubeck, D. Deposit date: 2022-09-07 Release date: 2023-02-22 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
8B0G	2C9, C5b9-CD59 structure Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ... Authors: Couves, E.C, Gardner, S, Bubeck, D. Deposit date: 2022-09-07 Release date: 2023-02-22 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
8B0F	CryoEM structure of C5b8-CD59 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Bubeck, D, Couves, E.C, Gardner, S. Deposit date: 2022-09-07 Release date: 2023-02-22 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
7NYC	cryoEM structure of 3C9-sMAC Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Menny, A, Couves, E.C, Bubeck, D. Deposit date: 2021-03-22 Release date: 2021-10-06 Last modified: 2021-11-17 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis of soluble membrane attack complex packaging for clearance. Nat Commun, 12, 2021
7NYD	cryoEM structure of 2C9-sMAC Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Menny, A, Couves, E.C, Bubeck, D. Deposit date: 2021-03-22 Release date: 2021-10-06 Last modified: 2021-11-17 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis of soluble membrane attack complex packaging for clearance. Nat Commun, 12, 2021
7NOZ	Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 alpha chain, Complement C3 beta chain, ... Authors: Lorenzen, J, Pedersen, D.V, Andersen, G.R. Deposit date: 2021-02-26 Release date: 2022-07-27 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging. Protein Sci., 31, 2022
7OP0	Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain. Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, ... Authors: Macpherson, A, van der Elsen, J.M.H, Schulze, M.E, Birtley, J.R. Deposit date: 2021-05-28 Release date: 2022-04-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.57 Å) Cite: The Chemical Synthesis of Knob Domain Antibody Fragments. Acs Chem.Biol., 16, 2021
7O7O	(h-alpha2M)4 semiactivated II state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7S	(h-alpha2M)4 plasmin-activated II state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7M	(h-alpha2M)4 native II Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (6.6 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7R	(h-alpha2M)4 plasmin-activated I state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7N	(h-alpha2M)4 semiactivated I state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (7.3 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7Q	(h-alpha2M)4 trypsin-activated state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7P	(h-alpha2M)4 activated state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-13 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
7O7L	(h-alpha2M)4 native I Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... Authors: Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. Deposit date: 2021-04-13 Release date: 2022-04-20 Last modified: 2022-05-11 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022

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