PDB: 159 resultsInfo pagesStatus searchChemie searchBIRD

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8Q2R	Crystal structure of YTHDC1 in complex with Compound 3 (ZA_431) Descriptor: 5-chloranyl-~{N},3-dimethyl-1~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Zalesak, F, Li, Y, Caflisch, A. Deposit date: 2023-08-03 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 3 (ZA_431) To Be Published
8Q2Q	Crystal structure of YTHDC1 in complex with Compound 2b (YL_32) Descriptor: 2-chloranyl-~{N},9-dimethyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1 Authors: Bedi, R.K, Li, Y, Caflisch, A. Deposit date: 2023-08-03 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal structure of YTHDC1 in complex with Compound 2b (YL_32) To Be Published
8BS6	Crystal structure of YTHDF3 disulfide mutant (closed conformation) Descriptor: YTH domain-containing family protein 3 Authors: Bedi, R.K, Li, Y, Caflisch, A. Deposit date: 2022-11-24 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Crystal structure of YTHDF3 disulfide mutant (closed conformation) To Be Published
8BS5	Crystal structure of YTHDF3 YTH domain open conformation Descriptor: DI(HYDROXYETHYL)ETHER, L(+)-TARTARIC ACID, YTH domain-containing family protein 3 Authors: Bedi, R.K, Caflisch, A. Deposit date: 2022-11-24 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Crystal structure of YTHDF3 YTH domain open conformation To Be Published
8BS4	Crystal structure of YTHDF1 YTH domain dimer Descriptor: ACETATE ION, GLYCEROL, YTH domain-containing family protein 1 Authors: Bedi, R.K, Caflisch, A. Deposit date: 2022-11-24 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of YTHDF1 YTH domain dimer To Be Published
7ZG4	Crystal structure of YTHDF2 with compound YLI_DF_042 Descriptor: GLYCEROL, N-methylpyrimidine-2-carboximidamide, SULFATE ION, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-04-01 Release date: 2022-04-20 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z93	Crystal structure of YTHDF2 with compound YLI_DF_022 Descriptor: 5-azanyl-6-ethyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, SULFATE ION, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-03-19 Release date: 2022-03-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z92	Crystal structure of YTHDF2 with compound YLI_DF_024 Descriptor: 5-azanyl-3,6-dimethyl-1H-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing family protein 2 Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-03-19 Release date: 2022-03-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z8X	Crystal structure of YTHDF2 with compound YLI_DC1_017 Descriptor: 6-methoxy-1H-pyrimidine-2,4-dione, SULFATE ION, YTH domain-containing family protein 2 Authors: Nachawati, R, Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-03-18 Release date: 2022-04-06 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z8W	Crystal structure of YTHDF2 with compound YLI_DC1_018 Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-03-18 Release date: 2022-03-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z8P	Crystal structure of YTHDF2 with compound ZA_166 Descriptor: 3-bromanyl-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, GLYCEROL, SULFATE ION, ... Authors: Nai, F, Zalesak, F, Li, Y, Caflisch, A. Deposit date: 2022-03-18 Release date: 2022-03-30 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z7F	Crystal structure of YTHDF2 with compound YLI_DC1_005 Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ... Authors: Nai, F, Li, Y, Dolbois, A, Caflisch, A. Deposit date: 2022-03-15 Release date: 2022-03-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z7B	Crystal structure of YTHDF2 with compound YLI_DC1_003 Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ... Authors: Nai, F, Li, Y, Dolbois, A, Caflisch, A. Deposit date: 2022-03-15 Release date: 2022-06-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z5M	Crystal structure of YTHDF2 with compound YLI_DC1_008 Descriptor: CHLORIDE ION, GLYCEROL, SULFATE ION, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-03-09 Release date: 2022-06-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z54	Crystal structure of YTHDF2 with compound YLI_DC1_006 Descriptor: 9-cyclopropyl-~{N}-methyl-purin-6-amine, CHLORIDE ION, GLYCEROL, ... Authors: Nai, F, Li, Y, Dolbois, A, Caflisch, A. Deposit date: 2022-03-07 Release date: 2022-06-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z4U	Crystal structure of YTHDF2 with compound YLI_DF_028 Descriptor: 6-cyclopropyl-3-methyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, GLYCEROL, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-03-04 Release date: 2022-03-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7Z26	Crystal structure of YTHDF2 YTH domain in complex with m6A RNA Descriptor: GLYCEROL, RNA (5'-R(P*(6MZ)P*CP*U)-3'), SULFATE ION, ... Authors: Nai, F, Nachawati, R, Li, Y, Caflisch, A. Deposit date: 2022-02-25 Release date: 2022-03-16 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7YZ8	Triclinic crystal structure of YTHDF1 YTH domain (544AVV546 mutant) Descriptor: THIOCYANATE ION, YTH domain-containing family protein 1 Authors: Dalle Vedove, A, Cazzanelli, G, Lolli, G. Deposit date: 2022-02-19 Release date: 2023-03-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pliability in the m 6 A-Binding Region Extends Druggability of YTH Domains. J.Chem.Inf.Model., 2024
7YYJ	Tetragonal crystal structure of YTHDF1 YTH domain (544AVV546 mutant) Descriptor: 1,2-ETHANEDIOL, THIOCYANATE ION, YTH domain-containing family protein 1 Authors: Dalle Vedove, A, Cazzanelli, G, Lolli, G. Deposit date: 2022-02-18 Release date: 2023-03-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Pliability in the m 6 A-Binding Region Extends Druggability of YTH Domains. J.Chem.Inf.Model., 2024
7YYF	Orthorombic crystal structure of YTHDF1 YTH domain (G459N mutant) form II Descriptor: YTH domain-containing family protein 1 Authors: Dalle Vedove, A, Cazzanelli, G, Lolli, G. Deposit date: 2022-02-17 Release date: 2023-03-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Pliability in the m 6 A-Binding Region Extends Druggability of YTH Domains. J.Chem.Inf.Model., 2024
7YYE	Orthorombic crystal structure of YTHDF1 YTH domain (G459N mutant) form I Descriptor: 1,2-ETHANEDIOL, MALONIC ACID, YTH domain-containing family protein 1 Authors: Dalle Vedove, A, Cazzanelli, G, Lolli, G. Deposit date: 2022-02-17 Release date: 2023-03-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Pliability in the m 6 A-Binding Region Extends Druggability of YTH Domains. J.Chem.Inf.Model., 2024
7YXE	Crystal structure of YTHDF2 with compound ZA_143 Descriptor: GLYCEROL, SODIUM ION, SULFATE ION, ... Authors: Nai, F, Zalesak, F, Li, Y, Caflisch, A. Deposit date: 2022-02-15 Release date: 2022-03-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7YX6	Crystal structure of YTHDF2 with compound YLI_DF_027 Descriptor: 6-ethyl-1H-pyrimidine-2,4-dione, GLYCEROL, SULFATE ION, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-02-15 Release date: 2022-02-23 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7YWB	Crystal structure of YTHDF2 in complex with N6-Methyladenine Descriptor: CHLORIDE ION, GLYCEROL, N-METHYL-9H-PURIN-6-AMINE, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-02-12 Release date: 2022-03-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022
7R5W	Crystal structure of YTHDF2 with compound YLI_DF_029 Descriptor: 6-cyclopropyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, GLYCEROL, ... Authors: Nai, F, Li, Y, Caflisch, A. Deposit date: 2022-02-11 Release date: 2022-03-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13, 2022

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