7R5W

Crystal structure of YTHDF2 with compound YLI_DF_029

Summary for 7R5W

Entry DOI	10.2210/pdb7r5w/pdb
Descriptor	YTH domain-containing family protein 2, SULFATE ION, 6-cyclopropyl-1H-pyrimidine-2,4-dione, ... (6 entities in total)
Functional Keywords	epitranscriptomic reader, m6a reader, rna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	39963.56
Authors	Nai, F.,Li, Y.,Caflisch, A. (deposition date: 2022-02-11, release date: 2022-03-16, Last modification date: 2024-01-31)
Primary citation	Nai, F.,Nachawati, R.,Zalesak, F.,Wang, X.,Li, Y.,Caflisch, A. Fragment Ligands of the m 6 A-RNA Reader YTHDF2. Acs Med.Chem.Lett., 13:1500-1509, 2022 Cited by PubMed: 36110386 DOI: 10.1021/acsmedchemlett.2c00303 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation