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7Z8W

Crystal structure of YTHDF2 with compound YLI_DC1_018

Summary for 7Z8W
Entry DOI10.2210/pdb7z8w/pdb
DescriptorYTH domain-containing family protein 2, SULFATE ION, ~{N}-cyclopropyl-3-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, ... (6 entities in total)
Functional Keywordsepitranscriptomic reader, m6a reader, rna binding protein
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight40091.43
Authors
Nai, F.,Li, Y.,Caflisch, A. (deposition date: 2022-03-18, release date: 2022-03-30, Last modification date: 2024-01-31)
Primary citationNai, F.,Nachawati, R.,Zalesak, F.,Wang, X.,Li, Y.,Caflisch, A.
Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13:1500-1509, 2022
Cited by
PubMed: 36110386
DOI: 10.1021/acsmedchemlett.2c00303
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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