7YX6

Crystal structure of YTHDF2 with compound YLI_DF_027

Summary for 7YX6

• Entry DOI: 10.2210/pdb7yx6/pdb
• Descriptor: YTH domain-containing family protein 2, SULFATE ION, 6-ethyl-1H-pyrimidine-2,4-dione, ... (5 entities in total)
• Functional Keywords: epitranscriptomic reader, m6a reader, rna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 39488.35

Authors

Nai, F.,Li, Y.,Caflisch, A. (deposition date: 2022-02-15, release date: 2022-02-23, Last modification date: 2024-01-31)

• Primary citation: Nai, F.,Nachawati, R.,Zalesak, F.,Wang, X.,Li, Y.,Caflisch, A.; Fragment Ligands of the m 6 A-RNA Reader YTHDF2.; Acs Med.Chem.Lett., 13:1500-1509, 2022; PubMed: 36110386; DOI: 10.1021/acsmedchemlett.2c00303

Experimental method

X-RAY DIFFRACTION (1.8 Å)