PDB: 159 件ウェブページステータス検索Chemie searchBIRD

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8VDY	Crystal Structure of Delta 114-117 D-Dopachrome Tautomerase (D-DT) 分子名称: D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-18 公開日 2024-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 2024
8VG7	Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) 分子名称: D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-23 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 2024
8VFO	Crystal Structure of L117G Variant of D-Dopachrome Tautomerase (D-DT) 分子名称: CITRIC ACID, D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-21 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 2024
8VFW	Crystal Structure of V113N D-Dopachrome Tautomerase (D-DT) 分子名称: CITRIC ACID, D-dopachrome decarboxylase 著者 Parkins, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-22 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 2024
8VFL	Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 290K 分子名称: D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-21 公開日 2024-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 2024
8VFN	Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 310K 分子名称: D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-21 公開日 2024-05-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 2024
8VG5	Crystal Structure of V113N Variant of D-Dopachrome Tautomerase (D-DT) Bound with 4CPPC 分子名称: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, CITRIC ACID, D-dopachrome decarboxylase 著者 Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G. 登録日 2023-12-22 公開日 2024-05-01 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes. J.Med.Chem., 2024
9B0M	Crystal structure of Macrophage migration inhibitory factor from Plasmodium vivax 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, L-dopachrome isomerase 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-03-12 公開日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of Macrophage migration inhibitory factor from Plasmodium vivax To be published
3IJJ	Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer) 分子名称: (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... 著者 Crichlow, G.V, Cho, Y, Lolis, E.J. 登録日 2009-08-04 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
3IJG	Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013 分子名称: (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, CHLORIDE ION, Macrophage migration inhibitory factor 著者 Crichlow, G.V, Cho, Y, Lolis, E.J. 登録日 2009-08-04 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107, 2010
3KAN	D-dopachrome tautomerase (D-DT)/macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP 分子名称: 4-phenylpyrimidine, CHLORIDE ION, D-dopachrome tautomerase 著者 Zierow, S, Lolis, E. 登録日 2009-10-19 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28, 2014
4NWR	Computationally Designed Two-Component Self-Assembling Tetrahedral Cage T33-28 分子名称: Macrophage migration inhibitory factor-like protein, integron gene cassette protein 著者 McNamara, D.E, King, N.P, Bale, J.B, Sheffler, W, Baker, D, Yeates, T.O. 登録日 2013-12-06 公開日 2014-05-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Accurate design of co-assembling multi-component protein nanomaterials. Nature, 510, 2014
3JSF	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution 分子名称: 7-(2-fluorobenzyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION 著者 Mclean, L, Zhang, Y. 登録日 2009-09-10 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
3JSG	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution 分子名称: 7-(pyridin-3-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION 著者 Mclean, L, Zhang, Y. 登録日 2009-09-10 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
4P0H	Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with Dimethylformamide 分子名称: DIMETHYLFORMAMIDE, GLYCEROL, Macrophage migration inhibitory factor 著者 Pantouris, G, Lolis, E. 登録日 2014-02-21 公開日 2014-04-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
3JTU	Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 708 at 1.86a resolution 分子名称: 7-(pyridin-2-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION 著者 Mclean, L, Zhang, Y. 登録日 2009-09-14 公開日 2009-11-10 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009
4OYQ	(6-isothiocyanatohexyl)benzene inhibitor complexed with Macrophage Migration Inhibitory Factor 分子名称: 6-isothiocyanatohexylbenzene, GLYCEROL, Macrophage migration inhibitory factor, ... 著者 Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. 登録日 2014-02-12 公開日 2014-03-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 To be published To be published
4OSF	4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor 分子名称: CHLORIDE ION, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... 著者 Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. 登録日 2014-02-12 公開日 2014-03-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor Eur.J.Med.Chem., 93, 2015
3KER	D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP 分子名称: 4-phenylpyrimidine, CHLORIDE ION, D-dopachrome decarboxylase, ... 著者 Zierow, S, Lolis, E. 登録日 2009-10-26 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. Faseb J., 28, 2014
4P01	Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide 分子名称: CHLORIDE ION, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Pantouris, G, Lolis, E. 登録日 2014-02-19 公開日 2014-03-19 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4P7M	Crystal structure of Plasmodium falciparum MIF in complex with 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol 分子名称: 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol, Macrophage migration inhibitory factor-like protein 著者 Pantouris, G, Lolis, E. 登録日 2014-03-27 公開日 2014-10-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors. J.Med.Chem., 57, 2014
4P7S	Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine 分子名称: 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine, Macrophage migration inhibitory factor-like protein 著者 Pantouris, G, Lolis, E. 登録日 2014-03-27 公開日 2014-10-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors. J.Med.Chem., 57, 2014
3L5T	Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution 分子名称: 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, Macrophage migration inhibitory factor, SULFATE ION 著者 McLean, L, Zhang, Y. 登録日 2009-12-22 公開日 2010-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
4PKZ	Crystal structure of P1M mutant of Macrophage Migration Inhibitory Factor 分子名称: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION 著者 Pantouris, G, Lolis, E. 登録日 2014-05-15 公開日 2015-09-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
3L5R	Crystal structure of macrophage migration inhibitory factor (MIF) with phenylchromenone inhibitor at 1.94A resolution 分子名称: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, GLYCEROL, Macrophage migration inhibitory factor, ... 著者 McLean, L, Zhang, Y. 登録日 2009-12-22 公開日 2010-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

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