3JTU
Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 708 at 1.86a resolution
Summary for 3JTU
Entry DOI | 10.2210/pdb3jtu/pdb |
Related | 3JSF 3JSG |
Descriptor | Macrophage migration inhibitory factor, 7-(pyridin-2-ylmethyl)quinolin-8-ol, SULFATE ION, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, cytokine, cytoplasm, immune response, inflammatory response, innate immunity, isomerase, secreted, phosphoprotein |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P14174 |
Total number of polymer chains | 3 |
Total formula weight | 41179.56 |
Authors | Mclean, L.,Zhang, Y. (deposition date: 2009-09-14, release date: 2009-11-10, Last modification date: 2017-11-01) |
Primary citation | McLean, L.R.,Zhang, Y.,Li, H.,Li, Z.,Lukasczyk, U.,Choi, Y.M.,Han, Z.,Prisco, J.,Fordham, J.,Tsay, J.T.,Reiling, S.,Vaz, R.J.,Li, Y. Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19:6717-6720, 2009 Cited by PubMed: 19836948DOI: 10.1016/j.bmcl.2009.09.106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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