4RK8
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 | Descriptor: | 5-fluoro-2-{[(5Z)-5-(naphthalen-1-ylmethylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]amino}benzoic acid, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Ren, X, Zhu, J, Li, H. | Deposit date: | 2014-10-12 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356 TO BE PUBLISHED
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4CQ8
| Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with Genz-669178 | Descriptor: | 5-(4-cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropylthiophene-2-carboxamide, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... | Authors: | Rowland, P. | Deposit date: | 2014-02-12 | Release date: | 2014-04-30 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289, 2014
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4CQ9
| Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6253 | Descriptor: | 6-(3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-[1,2,4]triazolo[3,4-a]phthalazine, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... | Authors: | Rowland, P. | Deposit date: | 2014-02-12 | Release date: | 2014-04-30 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289, 2014
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4CQA
| Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) in complex with IDI-6273 | Descriptor: | 2-(4-chlorobenzyl)-8-ethoxy-1,3-dimethylcyclohepta[c]pyrrol-4(2H)-one, DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, ... | Authors: | Rowland, P. | Deposit date: | 2014-02-12 | Release date: | 2014-04-30 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth. J.Biol.Chem., 289, 2014
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7UT5
| Acinetobacter baumannii dihydroorotate dehydrogenase bound with inhibitor DSM186 | Descriptor: | (4R)-7-methyl-N-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]imidazo[1,2-a]pyrimidin-5-amine, Dihydroorotate dehydrogenase (quinone), FLAVIN MONONUCLEOTIDE, ... | Authors: | Deng, X, Phillips, M, Tomchick, D. | Deposit date: | 2022-04-26 | Release date: | 2022-12-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii. Proc.Natl.Acad.Sci.USA, 119, 2022
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4EF9
| Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate | Descriptor: | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Pinheiro, M.P, Emery, F.S, Nonato, M.C. | Deposit date: | 2012-03-29 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
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4EF8
| Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate | Descriptor: | Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Pinheiro, M.P, Emery, F.S, Nonato, M.C. | Deposit date: | 2012-03-29 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase. Curr.Pharm.Des., 19, 2013
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6E0B
| Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 | Descriptor: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Tomchick, D.R, Phillips, M.A, Deng, X. | Deposit date: | 2018-07-06 | Release date: | 2018-11-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5, 2019
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4LS0
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH01B0033 | Descriptor: | 2-{(E)-[2-(4-phenyl-1,3-thiazol-2-yl)hydrazinylidene]methyl}benzaldehyde, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Li, H, Ren, X, Zhu, J. | Deposit date: | 2013-07-21 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DHO1B0033 To be Published
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5H73
| Crystal structure of human DHODH with 18F | Descriptor: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Huang, J, Wu, D. | Deposit date: | 2016-11-16 | Release date: | 2017-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Crystal structure of human DHODH with 18F at 1.58 Angstroms resolution To Be Published
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6EBS
| Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in complex with orotate | Descriptor: | Dihydroorotate dehydrogenase (fumarate), FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Reis, R.A.G, Pinheiro, M.P, de Souza, A.L, Hunter, W.N, Nonato, M.C. | Deposit date: | 2018-08-07 | Release date: | 2019-08-21 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in complex with orotate To Be Published
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5HIN
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L compound | Descriptor: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Huang, J, Wu, D, Lu, Q, Yao, X. | Deposit date: | 2016-01-12 | Release date: | 2016-07-20 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L at 1.60 A resolution To Be Published
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4XQ6
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4LS2
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 | Descriptor: | 2-[(E)-{2-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Zhu, L, Li, H, Ren, X, Zhu, J. | Deposit date: | 2013-07-21 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A313 To be Published
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5HQE
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4LS1
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 | Descriptor: | 2-[(E)-{2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Zhu, L, Li, H, Ren, X, Zhu, J. | Deposit date: | 2013-07-21 | Release date: | 2014-07-23 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 To be Published
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4YLW
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound | Descriptor: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | Authors: | Wu, D, Ouyang, P, Lu, W, Huang, J. | Deposit date: | 2015-03-06 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound To Be Published
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1JQV
| The K213E mutant of Lactococcus lactis Dihydroorotate dehydrogenase A | Descriptor: | ACETIC ACID, Dihydroorotate dehydrogenase A, FLAVIN MONONUCLEOTIDE, ... | Authors: | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | Deposit date: | 2001-08-09 | Release date: | 2003-09-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
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1JRB
| The P56A mutant of Lactococcus lactis dihydroorotate dehydrogenase A | Descriptor: | FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A | Authors: | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | Deposit date: | 2001-08-13 | Release date: | 2003-09-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
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6ET4
| HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR | Descriptor: | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ACETIC ACID, CHLORIDE ION, ... | Authors: | Hakansson, M, Walse, B, Gustavsson, A.-L, Lain, S. | Deposit date: | 2017-10-25 | Release date: | 2018-03-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nat Commun, 9, 2018
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1JUB
| The K136E mutant of lactococcus lactis dihydroorotate dehydrogenase A | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | Deposit date: | 2001-08-24 | Release date: | 2003-09-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
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1JQX
| The R57A mutant of Lactococcus lactis dihydroorotate dehydrogenase A | Descriptor: | FLAVIN MONONUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | Deposit date: | 2001-08-09 | Release date: | 2003-09-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
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1JRC
| The N67A mutant of Lactococcus lactis dihydroorotate dehydrogenase A | Descriptor: | FLAVIN MONONUCLEOTIDE, OROTIC ACID, dihydroorotate dehydrogenase A | Authors: | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | Deposit date: | 2001-08-13 | Release date: | 2003-09-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
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1JUE
| 1.8 A resolution structure of native lactococcus lactis dihydroorotate dehydrogenase A | Descriptor: | ACETIC ACID, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Norager, S, Arent, S, Bjornberg, O, Ottosen, M, Lo Leggio, L, Jensen, K.F, Larsen, S. | Deposit date: | 2001-08-24 | Release date: | 2003-09-09 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Lactococcus lactis dihydroorotate dehydrogenase A mutants reveal important facets of the enzymatic function J.Biol.Chem., 278, 2003
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4ZMG
| Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 | Descriptor: | 1-(3,5-difluoro-3'-methoxybiphenyl-4-yl)-3-(1,3-thiazol-5-yl)urea, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | Authors: | Ren, X.L, Zhu, J.S, Zhu, L.L, Li, H.L. | Deposit date: | 2015-05-04 | Release date: | 2016-05-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 To Be Published
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