Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
4OTT
DownloadVisualize
BU of 4ott by Molmil
Crystal structure of the gamma-glutamyltranspeptidase from Bacillus licheniformis.
分子名称: Gamma glutamyl transpeptidase, Gamma-glutamyltranspeptidase, MAGNESIUM ION
著者Merlino, A.
登録日2014-02-14
公開日2014-07-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Low resolution X-ray structure of gamma-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion.
Biochim.Biophys.Acta, 1844, 2014
4OTU
DownloadVisualize
BU of 4otu by Molmil
Crystal structure of the gamma-glutamyltranspeptidase from Bacillus licheniformis in complex with L-Glutamate
分子名称: GLUTAMIC ACID, Gamma glutamyl transpeptidase, Gamma-glutamyltranspeptidase, ...
著者Merlino, A.
登録日2014-02-14
公開日2014-07-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.022 Å)
主引用文献Low resolution X-ray structure of gamma-glutamyltranspeptidase from Bacillus licheniformis: Opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion.
Biochim.Biophys.Acta, 1844, 2014
4Y23
DownloadVisualize
BU of 4y23 by Molmil
Crystal structure of T399A precursor mutant protein of gamma-glutamyl transpeptidase from Bacillus licheniformis
分子名称: Gamma glutamyl transpeptidase,Gamma-glutamyltranspeptidase, SODIUM ION
著者Pica, A, Merlino, A.
登録日2015-02-09
公開日2015-11-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献The maturation mechanism of gamma-glutamyl transpeptidases: Insights from the crystal structure of a precursor mimic of the enzyme from Bacillus licheniformis and from site-directed mutagenesis studies.
Biochim.Biophys.Acta, 1864, 2015
4Z9O
DownloadVisualize
BU of 4z9o by Molmil
Crystal Structure of human GGT1
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Terzyan, S.S, Hanigan, M.H.
登録日2015-04-10
公開日2015-06-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS.
J.Biol.Chem., 290, 2015
4ZBK
DownloadVisualize
BU of 4zbk by Molmil
Crystal Structure of human GGT1 in complex with GGsTop inhibitor
分子名称: (2S)-2-amino-4-[(S)-hydroxy(methoxy)phosphoryl]butanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Terzyan, S, Hanigan, M.
登録日2015-04-14
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS.
J.Biol.Chem., 290, 2015
4ZC6
DownloadVisualize
BU of 4zc6 by Molmil
Crystal Structure of human GGT1 in complex with Serine Borate
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Gamma-glutamyltranspeptidase 1 heavy chain, ...
著者Terzyan, S, Hanigan, M.
登録日2015-04-15
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS.
J.Biol.Chem., 290, 2015
4ZCG
DownloadVisualize
BU of 4zcg by Molmil
Crystal Structure of human GGT1 in complex with Glutamate (with all atoms of glutamate)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTAMIC ACID, ...
著者Terzyan, S, Hanigan, M.
登録日2015-04-15
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Human gamma-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS.
J.Biol.Chem., 290, 2015
5B5T
DownloadVisualize
BU of 5b5t by Molmil
Crystal Structure of Escherichia coli Gamma-Glutamyltranspeptidase in Complex with peptidyl phosphonate inhibitor 1b
分子名称: (2~{S})-2-azanyl-4-[(2~{R})-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-butan-2-yl]oxyphosphonoyl-butanoic acid, CALCIUM ION, Gamma-glutamyltranspeptidase large chain, ...
著者Wada, K, Fukuyama, K.
登録日2016-05-18
公開日2016-09-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Phosphonate-based irreversible inhibitors of human gamma-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity
Bioorg.Med.Chem., 24, 2016
5BPK
DownloadVisualize
BU of 5bpk by Molmil
Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
分子名称: (2S)-amino[(5S)-4,5-dihydro-1,2-oxazol-5-yl]acetic acid, 1,2-ETHANEDIOL, Gamma-glutamyltranspeptidase (Ggt)
著者Bolz, C, Bach, N.C, Meyer, H, Mueller, G, Dawidowski, M, Popowicz, G, Sieber, S.A, Skerra, A, Gerhard, M.
登録日2015-05-28
公開日2016-05-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
To Be Published
5HFT
DownloadVisualize
BU of 5hft by Molmil
Crystal structure of HpxW
分子名称: Gamma-glutamyltranspeptidase
著者Ealick, S.E, Hicks, K.A.
登録日2016-01-07
公開日2016-06-29
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.646 Å)
主引用文献Biochemical and structural characterization of Klebsiella pneumoniae oxamate amidohydrolase in the uric acid degradation pathway.
Acta Crystallogr D Struct Biol, 72, 2016
5V4Q
DownloadVisualize
BU of 5v4q by Molmil
Crystal Structure of human GGT1 in complex with DON
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5,5-dihydroxy-L-norleucine, CHLORIDE ION, ...
著者Terzyan, S, Hanigan, M.
登録日2017-03-10
公開日2017-04-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation.
Protein Sci., 26, 2017
5XLU
DownloadVisualize
BU of 5xlu by Molmil
High Resolution Crystal Structure of Bacillus Licheniformis Gamma Glutamyl Transpeptidase with Acivicin
分子名称: (2S)-AMINO[(5S)-3-CHLORO-4,5-DIHYDROISOXAZOL-5-YL]ACETIC ACID, CALCIUM ION, GLYCEROL, ...
著者Kumari, S, Goel, M, Gupta, R, Pal, R.
登録日2017-05-11
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献High Resolution Crystal Structure of Bacillus Licheniformis Gamma Glutamyl Transpeptidase with Acivicin
To Be Published
5Y9B
DownloadVisualize
BU of 5y9b by Molmil
Crystal structure of Bacillus licheniformis Gamma glutamyl transpeptidase with DON
分子名称: 1,2-ETHANEDIOL, 6-DIAZENYL-5-OXO-L-NORLEUCINE, CALCIUM ION, ...
著者Goel, M, Kumari, S, Pal, R, Gupta, R.
登録日2017-08-24
公開日2018-08-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of Bacillus licheniformis Gamma glutamyl transpeptidase with Azaserine
To Be Published
6J3A
DownloadVisualize
BU of 6j3a by Molmil
Structure of LmbA2991HD
分子名称: Gamma-glutamyltranspeptidase
著者Song, Y.
登録日2019-01-04
公開日2020-01-15
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Structure of LmbA2991HD
To Be Published
6J3I
DownloadVisualize
BU of 6j3i by Molmil
Structure of LmbA2991T421A
分子名称: Gamma-glutamyltranspeptidase
著者Song, Y.
登録日2019-01-04
公開日2020-01-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of LmbA2991T421A
To Be Published
6XPB
DownloadVisualize
BU of 6xpb by Molmil
Structure of human GGT1 in complex with 2-amino-4-(((1-((carboxymethyl)amino)-1-oxobutan-2-yl)oxy)(phenoxy)phosphoryl)butanoic acid (ACPB) molecule
分子名称: 2,2-diamino-4-[(S)-({(2S)-1-[(carboxymethyl)amino]-1-oxobutan-2-yl}oxy)(hydroxy)phosphanyl]butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Terzyan, S.S, Hanigan, M.H.
登録日2020-07-08
公開日2020-11-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.
J.Biol.Chem., 296, 2020
6XPC
DownloadVisualize
BU of 6xpc by Molmil
Structure of human GGT1 in complex with full GSH molecule
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLUTATHIONE, ...
著者Terzyan, S.S, Hanigan, M.
登録日2020-07-08
公開日2020-11-25
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.
J.Biol.Chem., 296, 2020
7D9E
DownloadVisualize
BU of 7d9e by Molmil
Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with L-DON
分子名称: 6-DIAZENYL-5-OXO-L-NORLEUCINE, GLYCEROL, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03
著者Hibi, T, Sano, C, Itoh, T, Wakayama, M.
登録日2020-10-13
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens.
Biochem.Biophys.Res.Commun., 534, 2021
7D9W
DownloadVisualize
BU of 7d9w by Molmil
Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with L-DON
分子名称: 6-DIAZENYL-5-OXO-L-NORLEUCINE, GLYCINE, Gamma-glutamyltransferase 1 Threonine peptidase. MEROPS family T03
著者Hibi, T, Sano, C, Putthapong, P, Hayashi, J, Itoh, T, Wakayama, M.
登録日2020-10-14
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens.
Biochem.Biophys.Res.Commun., 534, 2021
7D9X
DownloadVisualize
BU of 7d9x by Molmil
Highly active mutant W525D of Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens
分子名称: GAMMA-BUTYROLACTONE, GLYCEROL, GLYCINE, ...
著者Hibi, T, Sano, C, Itoh, T, Wakayama, M.
登録日2020-10-14
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Mutagenesis and structure-based analysis of the role of Tryptophan525 of gamma-glutamyltranspeptidase from Pseudomonas nitroreducens.
Biochem.Biophys.Res.Commun., 534, 2021
7LA5
DownloadVisualize
BU of 7la5 by Molmil
Structure of human GGT1 in complex with Lnt1-172 compound.
分子名称: (2R)-4-borono-2-{[(1H-imidazol-4-yl)methyl]amino}butanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Terzyan, S.S, Hanigan, M, Nguen, L.
登録日2021-01-05
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structure of human GGT1 in complex with Lnt1-172 compound.
To Be Published
7LBC
DownloadVisualize
BU of 7lbc by Molmil
Structure of human GGT1 in complex with Lnt2-65 compound
分子名称: (2R)-2-[(2-aminoethyl)amino]-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Terzyan, S.S, Hanigan, M.
登録日2021-01-07
公開日2022-02-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase.
Bioorg.Med.Chem., 73, 2022
7LD9
DownloadVisualize
BU of 7ld9 by Molmil
Structure of human GGT1 in complex with ABBA
分子名称: (2R)-2-amino-4-boronobutanoic acid, (2S)-2-amino-4-boronobutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Terzyan, S.S, Hanigan, M.
登録日2021-01-12
公開日2022-02-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase.
Bioorg.Med.Chem., 73, 2022
<12

 

219869

件を2024-05-15に公開中

PDB statisticsPDBj update infoContact PDBjnumon