PDB: 54 件ウェブページステータス検索Chemie searchBIRD

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1WXZ	Crystal structure of adenosine deaminase ligated with a potent inhibitor 分子名称: 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2005-02-02 公開日 2005-08-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism J.Med.Chem., 48, 2005
3KM8	Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine 分子名称: 9-DEAZAINOSINE, Adenosine deaminase, ZINC ION 著者 Fan, X, Gao, Y. 登録日 2009-11-10 公開日 2010-10-20 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The Catalytic Mechanism of Adenosine Deaminase from Mouse: An Experimental and Theoretical Study To be Published
1NDV	Crystal Structure of Adenosine Deaminase complexed with FR117016 分子名称: Adenosine deaminase, N''-(4-(5-((1H-BENZIMIDAZOL-2-YLAMINO)METHYL)-2-THIENYL)-1,3-THIAZOL-2-YL)GUANIDINE, ZINC ION 著者 Kinoshita, T. 登録日 2002-12-09 公開日 2003-12-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126, 2004
3RYS	The crystal structure of adenine deaminase (AAur1117) from Arthrobacter aurescens 分子名称: ADENINE, Adenosine deaminase 1, ZINC ION 著者 Zhang, Z, Goble, A.M, Raushel, F.M, Swaminathan, S. 登録日 2011-05-11 公開日 2011-05-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 The crystal structure of adenine deaminase (AAur1117) from Arthrobacter aurescens To be Published
1NDW	Crystal Structure of Adenosine Deaminase Complexed with FR221647 分子名称: 1-((1R)-1-(HYDROXYMETHYL)-3-PHENYLPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2002-12-09 公開日 2003-12-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126, 2004
1NDY	Crystal Structure of Adenosine Deaminase Complexed with FR230513 分子名称: 1-((1R)-1-(HYDROXYMETHYL)-3-(1-NAPHTHYL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2002-12-09 公開日 2003-12-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126, 2004
1NDZ	Crystal Structure of Adenosine Deaminase Complexed with FR235999 分子名称: 1-((1R)-1-(HYDROXYMETHYL)-3-(6-((3-(1-METHYL-1H-BENZIMIDAZOL-2-YL)PROPANOYL)AMINO)-1H-INDOL-1-YL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2002-12-09 公開日 2003-12-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126, 2004
3MVT	Crystal structure of apo mADA at 2.2A resolution 分子名称: Adenosine deaminase, CHLORIDE ION, GLYCEROL 著者 Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C. 登録日 2010-05-04 公開日 2010-10-13 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The role of Zn2+ on the structure and stability of murine adenosine deaminase. J.Phys.Chem.B, 114, 2010
3MVI	Crystal structure of holo mADA at 1.6 A resolution 分子名称: Adenosine deaminase, GLYCEROL, ZINC ION 著者 Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C. 登録日 2010-05-04 公開日 2010-11-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 The role of Zn2+ on the structure and stability of murine adenosine deaminase. J.Phys.Chem.B, 114, 2010
1O5R	Crystal structure of adenosine deaminase complexed with a potent inhibitor 分子名称: 1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2003-10-05 公開日 2004-09-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors J.Med.Chem., 47, 2004
3T1G	Engineering of organophosphate hydrolase by computational design and directed evolution 分子名称: CALCIUM ION, ZINC ION, organophosphate hydrolase 著者 Takeuchi, R, Stoddard, B.L. 登録日 2011-07-21 公開日 2012-02-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nat.Chem.Biol., 8, 2012
2ADA	ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS 分子名称: 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1994-12-02 公開日 1995-03-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. Science, 252, 1991
2AMX	Crystal structure of Plasmodium Yoelii Adenosine deaminase (PY02076) 分子名称: COBALT (II) ION, UNKNOWN ATOM OR ION, adenosine deaminase 著者 Dong, A, Vedadi, M, Wasney, G, Zhao, Y, Lew, J, Alam, Z, Melone, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Amani, M, Structural Genomics Consortium (SGC) 登録日 2005-08-10 公開日 2005-09-20 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol.Biochem.Parasitol., 151, 2007
1V7A	Crystal structures of adenosine deaminase complexed with potent inhibitors 分子名称: 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE, ZINC ION, adenosine deaminase 著者 Kinoshita, T. 登録日 2003-12-14 公開日 2004-12-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors J.Med.Chem., 47, 2004
1UML	Crystal structure of adenosine deaminase complexed with a potent inhibitor FR233624 分子名称: 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2003-10-03 公開日 2004-09-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors J.Med.Chem., 47, 2004
1V79	Crystal structures of adenosine deaminase complexed with potent inhibitors 分子名称: 1-{(1R,2S)-1-[2-(2,3,-DICHLOROPHENYL)ETHYL]-2-HYDROXYPROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION 著者 Kinoshita, T. 登録日 2003-12-14 公開日 2004-12-21 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors J.Med.Chem., 47, 2004
1UIO	ADENOSINE DEAMINASE (HIS 238 ALA MUTANT) 分子名称: 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE, ADENOSINE DEAMINASE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1996-08-30 公開日 1997-06-24 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996
1UIP	ADENOSINE DEAMINASE (HIS 238 GLU MUTANT) 分子名称: ADENOSINE DEAMINASE, PURINE RIBOSIDE, ZINC ION 著者 Wilson, D.K, Quiocho, F.A. 登録日 1996-08-30 公開日 1997-06-24 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation. Biochemistry, 35, 1996
6IJP	The structure of the ADAL-IMP complex 分子名称: Adenosine/AMP deaminase family protein, INOSINIC ACID, ZINC ION 著者 Xie, W, Jia, Q. 登録日 2018-10-11 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Alternative conformation induced by substrate binding for Arabidopsis thalianaN6-methyl-AMP deaminase. Nucleic Acids Res., 47, 2019
6IV5	Crystal structure of arabidopsis N6-mAMP deaminase MAPDA 分子名称: Adenosine/AMP deaminase family protein, PHOSPHATE ION, ZINC ION 著者 Wu, B.X, Zhang, D, Nie, H.B, Shen, S.L, Li, S.S, Patel, D.J. 登録日 2018-12-02 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.749 Å) 主引用文献 Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing. Rna Biol., 16, 2019
6II7	Crystal structure of Plasmodium falciparum adenosine deaminase C27Q+L227I mutant co-complexed with Zn ion, hypoxanthine and inosine 分子名称: Adenosine deaminase, HYPOXANTHINE, INOSINE, ... 著者 Chitnumsub, P, Jaruwat, A. 登録日 2018-10-03 公開日 2019-05-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.48 Å) 主引用文献 Crystal structure of Plasmodium falciparum adenosine deaminase reveals a novel binding pocket for inosine. Arch. Biochem. Biophys., 667, 2019
6IJN	The D295N mutant of the N6-methyl-AMP deaminase from Arabidopsis thaliana complexed with N6m-AMP 分子名称: Adenosine/AMP deaminase family protein, N6-METHYLADENOSINE-5'-MONOPHOSPHATE 著者 Xie, W, Jia, Q. 登録日 2018-10-10 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Alternative conformation induced by substrate binding for Arabidopsis thalianaN6-methyl-AMP deaminase. Nucleic Acids Res., 47, 2019
6IJM	Apo structure of the N6-methyl-AMP Deaminase from Arabidopsis thaliana 分子名称: Adenosine/AMP deaminase family protein, ZINC ION 著者 Xie, W, Jia, Q. 登録日 2018-10-10 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.016 Å) 主引用文献 Alternative conformation induced by substrate binding for Arabidopsis thalianaN6-methyl-AMP deaminase. Nucleic Acids Res., 47, 2019
6J23	Crystal structure of arabidopsis ADAL complexed with GMP 分子名称: Adenosine/AMP deaminase family protein, GUANOSINE-5'-MONOPHOSPHATE, ZINC ION 著者 Wu, B.X, Zhang, D, Nie, H.B, Shen, S.L, Li, S.S, Patel, D.J. 登録日 2018-12-30 公開日 2019-02-27 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing. Rna Biol., 16, 2019
6J4T	Crystal structure of arabidopsis ADAL complexed with IMP 分子名称: Adenosine/AMP deaminase family protein, INOSINIC ACID, ZINC ION 著者 Wu, B.X, Zhang, D, Nie, H.B, Shen, S.L, Li, S.S, Patel, D.J. 登録日 2019-01-10 公開日 2019-07-31 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing. Rna Biol., 16, 2019

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