8SVE
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6X93
| Interleukin-10 signaling complex with IL-10RA and IL-10RB | Descriptor: | Interleukin-10, Interleukin-10 receptor subunit alpha, Interleukin-10 receptor subunit beta | Authors: | Saxton, R.A, Tsutsumi, N, Gati, C, Garcia, K.C. | Deposit date: | 2020-06-02 | Release date: | 2021-03-17 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Science, 371, 2021
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4X51
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4DOH
| IL20/IL201/IL20R2 Ternary Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-20, Interleukin-20 receptor subunit alpha, ... | Authors: | Logsdon, N.J, Walter, M.R. | Deposit date: | 2012-02-09 | Release date: | 2012-07-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc.Natl.Acad.Sci.USA, 109, 2012
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2H24
| Crystal structure of human IL-10 | Descriptor: | Interleukin-10 | Authors: | Yoon, S.I, Walter, M.R. | Deposit date: | 2006-05-18 | Release date: | 2006-10-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. J.Biol.Chem., 281, 2006
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1Y6K
| Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain | Descriptor: | Interleukin-10, Interleukin-10 receptor alpha chain | Authors: | Yoon, S.I, Jones, B.C, Josepson, K, Logsdon, N.J, Walter, M.R. | Deposit date: | 2004-12-06 | Release date: | 2005-12-20 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure, 13, 2005
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1Y6M
| Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain | Descriptor: | Interleukin-10 receptor alpha chain, Viral interleukin-10 homolog | Authors: | Yoon, S.I, Jones, B.C, Logsdon, N.J, Walter, M.R. | Deposit date: | 2004-12-06 | Release date: | 2005-05-03 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure, 13, 2005
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1Y6N
| Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain | Descriptor: | Interleukin-10 receptor alpha chain, Viral interleukin-10 homolog | Authors: | Yoon, S.I, Jones, B.C, Logsdon, N.J, Walter, M.R. | Deposit date: | 2004-12-06 | Release date: | 2005-05-03 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain. Structure, 13, 2005
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1N1F
| Crystal Structure of Human Interleukin-19 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, interleukin-19 | Authors: | Chang, C, Magracheva, E, Kozlov, S, Fong, S, Tobin, G, Kotenko, S, Wlodawer, A, Zdanov, A. | Deposit date: | 2002-10-17 | Release date: | 2003-02-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of interleukin-19 defines a new subfamily of helical cytokines J.Biol.Chem., 278, 2003
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1LK3
| ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT | Descriptor: | 9D7 Heavy Chain, 9D7 Light Chain, Interleukin-10 | Authors: | Josephson, K, Jones, B.C, Walter, L.J, DiGiacomo, R, Indelicato, S.R, Walter, M.R. | Deposit date: | 2002-04-23 | Release date: | 2002-07-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography. Structure, 10, 2002
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1LQS
| CRYSTAL STRUCTURE OF HUMAN CYTOMEGALOVIRUS IL-10 BOUND TO SOLUBLE HUMAN IL-10R1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-10 RECEPTOR ALPHA CHAIN, INTERLEUKIN-10-LIKE PROTEIN | Authors: | Jones, B.C, Logsdon, N.J, Josephson, K, Cook, J, Barry, P.A, Walter, M.R. | Deposit date: | 2002-05-13 | Release date: | 2002-07-17 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Proc.Natl.Acad.Sci.USA, 99, 2002
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1J7V
| HUMAN IL-10 / IL-10R1 COMPLEX | Descriptor: | INTERLEUKIN-10, INTERLEUKIN-10 RECEPTOR ALPHA CHAIN | Authors: | Josephson, K, Logsdon, N, Walter, M.R. | Deposit date: | 2001-05-18 | Release date: | 2001-09-19 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity, 15, 2001
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1VLK
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1INR
| CYTOKINE SYNTHESIS | Descriptor: | INTERLEUKIN-10 | Authors: | Walter, M.R. | Deposit date: | 1995-07-31 | Release date: | 1996-10-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of interleukin 10 reveals an interferon gamma-like fold. Biochemistry, 34, 1995
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2ILK
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1ILK
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