1VLK

STRUCTURE OF VIRAL INTERLEUKIN-10

Summary for 1VLK

• Entry DOI: 10.2210/pdb1vlk/pdb
• Descriptor: VIRAL INTERLEUKIN-10 (2 entities in total)
• Functional Keywords: cytokine, glycoprotein
• Biological source: Human herpesvirus 4 (Epstein-Barr virus)
• Cellular location: Secreted (Potential): P03180
• Total number of polymer chains: 1
• Total formula weight: 17162.71

Authors

Zdanov, A.,Schalk-Hihi, C.,Wlodawer, A. (deposition date: 1997-02-14, release date: 1997-04-01, Last modification date: 2024-10-23)

Primary citation

Zdanov, A.,Schalk-Hihi, C.,Menon, S.,Moore, K.W.,Wlodawer, A.
Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10.
J.Mol.Biol., 268:460-467, 1997

PubMed Abstract: The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.

PubMed: 9159483
DOI: 10.1006/jmbi.1997.0990

Experimental method

X-RAY DIFFRACTION (1.9 Å)