6VWU
 
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6YE3
 | | IL-2 in complex with a Fab fragment from UFKA-20 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chains: A,D,G, Chains: B,E,H, ... | | Authors: | Karakus, U, Mittl, P, Boyman, O. | | Deposit date: | 2020-03-23 | | Release date: | 2020-12-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species.
Sci Transl Med, 12, 2020
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7DR4
 | | Complex of anti-human IL-2 antibody and human IL-2 | | Descriptor: | Interleukin-2, anti-human IL-2 antibody, mouse Ig G, ... | | Authors: | Kim, M.S, Kim, J.E. | | Deposit date: | 2020-12-25 | | Release date: | 2021-04-14 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity.
Oncoimmunology, 10, 2021
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7M2G
 | | INTERLEUKIN-2 (human) mutant P65K, C125S | | Descriptor: | GLYCEROL, Interleukin-2, SULFATE ION | | Authors: | Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M. | | Deposit date: | 2021-03-16 | | Release date: | 2021-08-04 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Nat Commun, 12, 2021
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7RA9
 | | Designed StabIL-2 seq1 | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION | | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | | Deposit date: | 2021-06-30 | | Release date: | 2022-03-16 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7RAA
 | | Designed StabIL-2 seq15 | | Descriptor: | Interleukin-2, MAGNESIUM ION | | Authors: | Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. | | Deposit date: | 2021-06-30 | | Release date: | 2022-03-16 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7ZMZ
 | | Engineered Interleukin 2 bound to CD25 receptor | | Descriptor: | Interleukin-2, Interleukin-2 receptor subunit alpha | | Authors: | Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S. | | Deposit date: | 2022-04-20 | | Release date: | 2022-12-14 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Sci Immunol, 7, 2022
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