PDB: 354 件ウェブページステータス検索Chemie searchBIRD

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5YWA	Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (CTD class 2 at 6.1A) 分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Chen, L, Wu, J.X. 登録日 2017-11-29 公開日 2018-05-02 最終更新日 2018-06-13 実験手法 ELECTRON MICROSCOPY (6.1 Å) 主引用文献 Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018
6A6M	Crystal structure of an outward-open nucleotide-bound state of the eukaryotic ABC multidrug transporter CmABCB1 分子名称: ATP-binding cassette, sub-family B, member 1, ... 著者 Kato, H, Nakatsu, T, Kodan, A. 登録日 2018-06-28 公開日 2019-02-20 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1. Nat Commun, 10, 2019
6A6N	Crystal structure of an inward-open apo state of the eukaryotic ABC multidrug transporter CmABCB1 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP-binding cassette, sub-family B, ... 著者 Kato, H, Nakatsu, T, Kodan, A. 登録日 2018-06-28 公開日 2019-01-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.02 Å) 主引用文献 Inward- and outward-facing X-ray crystal structures of homodimeric P-glycoprotein CmABCB1. Nat Commun, 10, 2019
6BAA	Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide 分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... 著者 Martin, G.M, Yoshioka, C, Shyng, S.L. 登録日 2017-10-12 公開日 2017-11-01 最終更新日 2019-12-25 実験手法 ELECTRON MICROSCOPY (3.63 Å) 主引用文献 Anti-diabetic drug binding site in a mammalian KATPchannel revealed by Cryo-EM. Elife, 6, 2017
6BL6	Crystallization of lipid A transporter MsbA from Salmonella typhimurium 分子名称: Lipid A export ATP-binding/permease protein MsbA 著者 Padayatti, P.S, Stanfield, R.L, Zhang, Q, Wilson, I.A, Lee, S.C. 登録日 2017-11-09 公開日 2019-01-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Insights into the Lipid A Transport Pathway in MsbA. Structure, 27, 2019
6BPP	E. coli MsbA in complex with LPS and inhibitor G092 分子名称: (2E)-3-{6-[(1S)-1-(3-amino-2,6-dichlorophenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 3-HYDROXY-TETRADECANOIC ACID, ... 著者 Ho, H, Koth, C.M, Payandeh, J. 登録日 2017-11-24 公開日 2018-05-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature, 557, 2018
6BHU	Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, MAGNESIUM ION, ... 著者 Johnson, Z.L, Chen, J. 登録日 2017-10-31 公開日 2017-12-27 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1. Cell, 172, 2018
6BPL	E. coli MsbA in complex with LPS and inhibitor G907 分子名称: (2E)-3-{6-[(1S)-1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-amino-2-deoxy-alpha-D-glucopyranose, ... 著者 Ho, H, Koth, C.M, Payandeh, J. 登録日 2017-11-23 公開日 2018-05-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.908 Å) 主引用文献 Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature, 557, 2018
6C0V	Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance protein 1 著者 Kim, Y.J, Chen, J. 登録日 2018-01-02 公開日 2018-01-31 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation. Science, 359, 2018
6C3P	Cryo-EM structure of human KATP bound to ATP and ADP in propeller form 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... 著者 Lee, K.P.K, Chen, J, MacKinnon, R. 登録日 2018-01-10 公開日 2018-01-24 実験手法 ELECTRON MICROSCOPY (5.6 Å) 主引用文献 Molecular structure of human KATP in complex with ATP and ADP. Elife, 6, 2017
6C3O	Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... 著者 Lee, K.P.K, Chen, J, MacKinnon, R. 登録日 2018-01-10 公開日 2018-01-31 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular structure of human KATP in complex with ATP and ADP Elife, 6, 2017
7M33	The structure of Bacillus subtilis BmrCD in the inward-facing conformation bound to Hoechst-33342 and ATP 分子名称: 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ... 著者 Thaker, T.M, Tomasiak, T.M. 登録日 2021-03-18 公開日 2022-01-05 最終更新日 2022-02-09 実験手法 ELECTRON MICROSCOPY (3.55 Å) 主引用文献 Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter. Nat.Chem.Biol., 18, 2022
7M68	E1435Q Ycf1 mutant in inward-facing narrow conformation 分子名称: Metal resistance protein YCF1 著者 Khandelwal, N.K, Millan, C.R, Thaker, T.M, Tomasiak, T.M. 登録日 2021-03-25 公開日 2022-04-06 最終更新日 2022-10-19 実験手法 ELECTRON MICROSCOPY (4.04 Å) 主引用文献 The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation. Nat Commun, 13, 2022
7M69	E1435Q Ycf1 mutant in inward-facing wide conformation 分子名称: Metal resistance protein YCF1 著者 Khandelwal, N.K, Millan, C.R, Thaker, T.M, Tomasiak, T.M. 登録日 2021-03-25 公開日 2022-04-06 最終更新日 2022-10-19 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation. Nat Commun, 13, 2022
7MPE	Cryo-EM structure of the yeast cadmium factor 1 protein (Ycf1p) 分子名称: Metal resistance protein YCF1 著者 Bickers, S.C, Benlekbir, S, Rubinstein, J.L, Kanelis, V. 登録日 2021-05-04 公開日 2021-06-02 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters. Proc.Natl.Acad.Sci.USA, 118, 2021
7MET	A. baumannii MsbA in complex with TBT1 decoupler 分子名称: 2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid, ATP-dependent lipid A-core flippase 著者 Thelot, F, Liao, M. 登録日 2021-04-07 公開日 2021-10-06 最終更新日 2021-11-10 実験手法 ELECTRON MICROSCOPY (3.97 Å) 主引用文献 Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374, 2021
7MEW	E. coli MsbA in complex with G247 分子名称: (2E)-3-{1-cyclopropyl-7-[(1S)-1-(3,6-dichloro-2-fluorophenyl)ethoxy]naphthalen-2-yl}prop-2-enoic acid, ATP-dependent lipid A-core flippase 著者 Thelot, F, Liao, M. 登録日 2021-04-08 公開日 2021-10-06 最終更新日 2021-11-10 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Distinct allosteric mechanisms of first-generation MsbA inhibitors. Science, 374, 2021
7MJP	Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Sung, M.W, Shyng, S.L. 登録日 2021-04-20 公開日 2021-10-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021
7MJQ	Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 8, ... 著者 Sung, M.W, Shyng, S.L. 登録日 2021-04-20 公開日 2021-10-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021
7MJO	Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... 著者 Sung, M.W, Shyng, S.L. 登録日 2021-04-20 公開日 2021-10-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021
7N5B	Structure of AtAtm3 in the outward-facing conformation 分子名称: ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Fan, C, Rees, D.C. 登録日 2021-06-05 公開日 2022-04-13 最終更新日 2022-04-20 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
7N58	Structure of AtAtm3 in the inward-facing conformation 分子名称: ABC transporter B family member 25, mitochondrial 著者 Fan, C, Rees, D.C. 登録日 2021-06-05 公開日 2022-04-13 最終更新日 2022-04-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
7N59	Structure of AtAtm3 in the inward-facing conformation with GSSG bound 分子名称: ABC transporter B family member 25, mitochondrial, OXIDIZED GLUTATHIONE DISULFIDE 著者 Fan, C, Rees, D.C. 登録日 2021-06-05 公開日 2022-04-13 最終更新日 2022-04-20 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
7N5A	Structure of AtAtm3 in the closed conformation 分子名称: ABC transporter B family member 25, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Fan, C, Rees, D.C. 登録日 2021-06-05 公開日 2022-04-13 最終更新日 2022-04-20 実験手法 ELECTRON MICROSCOPY (3.95 Å) 主引用文献 Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters. Elife, 11, 2022
7MIT	Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 1 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... 著者 Sung, M.W, Shyng, S.L. 登録日 2021-04-17 公開日 2021-10-13 最終更新日 2023-08-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021

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