4ENE
| Structure of the N- and C-terminal trimmed ClC-ec1 Cl-/H+ antiporter and Fab Complex | Descriptor: | CHLORIDE ION, DECYL-BETA-D-MALTOPYRANOSIDE, H(+)/Cl(-) exchange transporter ClcA, ... | Authors: | Lim, H.H, Shane, T, Miller, C. | Deposit date: | 2012-04-13 | Release date: | 2012-12-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Intracellular proton access in a cl(-)/h(+) antiporter. Plos Biol., 10, 2012
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8TA3
| Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin | Descriptor: | CHLORIDE ION, Chloride channel protein 2 | Authors: | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | Deposit date: | 2023-06-26 | Release date: | 2024-01-31 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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1OTS
| Structure of the Escherichia coli ClC Chloride channel and Fab Complex | Descriptor: | CHLORIDE ION, Fab fragment (heavy chain), Fab fragment (light chain), ... | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | Deposit date: | 2003-03-22 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Gating the Selectivity Filter in ClC Chloride Channels Science, 300, 2003
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8GA1
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA5
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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7CQ5
| Structure of the human CLCN7-OSTM1 complex with ATP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Yang, G.H, Lu, Y.M, Zhang, Y.M, Jia, Y.T, Li, X.M, Lei, J.L. | Deposit date: | 2020-08-08 | Release date: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structure of the human CLCN7-OSTM1 complex with ATP To Be Published
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6V2J
| Crystal structure of ClC-ec1 triple mutant (E113Q, E148Q, E203Q) | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Maduke, M, Mathews, I.I, Chavan, T.S. | Deposit date: | 2019-11-24 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl - /H + transport cycle. Elife, 9, 2020
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6ADB
| Crystal structure of the E148N mutant CLC-ec1 in 20mM bromide | Descriptor: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment, ... | Authors: | Lim, H.-H, Park, K. | Deposit date: | 2018-07-31 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.692 Å) | Cite: | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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8TA2
| Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42 | Descriptor: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION, Chloride channel protein 2 | Authors: | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | Deposit date: | 2023-06-26 | Release date: | 2024-01-31 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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8TA4
| Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal | Descriptor: | CHLORIDE ION, Chloride channel protein 2 | Authors: | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | Deposit date: | 2023-06-26 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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8TA5
| Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal | Descriptor: | Chloride channel protein 2 | Authors: | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | Deposit date: | 2023-06-26 | Release date: | 2024-01-31 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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3DET
| Structure of the E148A, Y445A doubly ungated mutant of E.coli CLC_Ec1, Cl-/H+ antiporter | Descriptor: | Fab fragment, Heavy chain, Light chain, ... | Authors: | Jayaram, H, Accardi, A, Wu, F, Williams, C, Miller, C. | Deposit date: | 2008-06-10 | Release date: | 2008-06-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger Proc.Natl.Acad.Sci.USA, 105, 2008
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7JM7
| Structure of human CLC-7/OSTM1 complex | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dinonanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Schrecker, M, Hite, R. | Deposit date: | 2020-07-31 | Release date: | 2020-09-02 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1. Elife, 9, 2020
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7XA9
| Structure of Arabidopsis thaliana CLCa | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ... | Authors: | Ji, S, Jin, H, Kaiming, Z, Mingxing, W, Shanshan, L, Long, C. | Deposit date: | 2022-03-17 | Release date: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket. J.Biol.Chem., 299, 2023
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4KKL
| Structure of the E148A mutant of CLC-ec1 delta NC construct in 100mM fluoride | Descriptor: | FLUORIDE ION, Fab, heavy chain, ... | Authors: | Stockbridge, R.B, Lim, H.-H, Miller, C. | Deposit date: | 2013-05-06 | Release date: | 2013-08-21 | Last modified: | 2013-12-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Fluoride-dependent interruption of the transport cycle of a CLC Cl(-)/H(+) antiporter. Nat.Chem.Biol., 9, 2013
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4KK8
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4KJQ
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8GAH
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | Authors: | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | Deposit date: | 2023-02-22 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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3EJZ
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7CVT
| Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | Authors: | Park, K, Mersch, K, Robertson, J, Lim, H.-H. | Deposit date: | 2020-08-27 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface. J.Mol.Biol., 433, 2021
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7JM6
| Structure of chicken CLC-7 | Descriptor: | (2R)-3-{[(R)-hydroxy{[(1S,2R,3S,4S,5R,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dinonanoate, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | Authors: | Schrecker, M, Hite, R. | Deposit date: | 2020-07-31 | Release date: | 2020-09-02 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1. Elife, 9, 2020
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6AD7
| Crystal structure of the E148D mutant CLC-ec1 in 20 mM bromide | Descriptor: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | Authors: | Lim, H.-H, Park, K. | Deposit date: | 2018-07-31 | Release date: | 2019-08-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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8IAB
| The Arabidopsis CLCa transporter bound with chloride, ATP and PIP2 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chloride channel protein CLC-a, ... | Authors: | Yang, Z, Zhang, X, Zhang, P. | Deposit date: | 2023-02-08 | Release date: | 2023-08-02 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun, 14, 2023
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8JGV
| Cryo-EM structure of mClC-3_I607T with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, H(+)/Cl(-) exchange transporter 3 | Authors: | Wan, Y.Z.Q, Yang, F. | Deposit date: | 2023-05-21 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger. Nat Commun, 15, 2024
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4LOU
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