PDB: 285 件ウェブページステータス検索Chemie searchBIRD

---

4O9K	Crystal structure of the CBS pair of a putative D-arabinose 5-phosphate isomerase from Methylococcus capsulatus in complex with CMP-Kdo 分子名称: Arabinose 5-phosphate isomerase, CYTIDINE 5'-MONOPHOSPHATE 3-DEOXY-BETA-D-GULO-OCT-2-ULO-PYRANOSONIC ACID, GLYCEROL 著者 Shabalin, I.G, Cooper, D.R, Shumilin, I.A, Zimmerman, M.D, Majorek, K.A, Hammonds, J, Hillerich, B.S, Nawar, A, Bonanno, J, Seidel, R, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2014-01-02 公開日 2014-01-22 最終更新日 2022-04-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure and kinetic properties of D-arabinose 5-phosphate isomerase from Methylococcus capsulatus To be Published
4COO	Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution 分子名称: 1,2-ETHANEDIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ACETATE ION, ... 著者 McCorvie, T.J, Kopec, J, Vollamar, M, Strain-Damerell, C, Bushell, S, Bradley, A, Tallant, C, Kiyani, W, Froese, D.S, Carpenter, E.S, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. 登録日 2014-01-29 公開日 2014-03-05 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation. J.Biol.Chem., 289, 2014
4P1G	Crystal structure of the Bateman domain of murine magnesium transporter CNNM2 bound to AMP 分子名称: ADENOSINE MONOPHOSPHATE, Metal transporter CNNM2 著者 Corral-Rodriguez, M.A, Stuiver, M, Abascal-Palacios, G, Diercks, T, Oyenarte, I, Ereno-Orbea, J, Encinar, J.A, Spiwok, V, Terashima, H, Accardi, A, Muller, D, Martinez-Cruz, L.A. 登録日 2014-02-26 公開日 2015-03-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.603 Å) 主引用文献 Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 To Be Published
4P1O	Crystal structure of the Bateman domain of murine magnesium transporter CNNM2 bound to ATP-Mg 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Metal transporter CNNM2 著者 Corral-Rodriguez, M.A, Stuiver, M, Abascal-Palacios, G, Diercks, T, Oyenarte, I, Ereno-Orbea, J, Encinar, J.A, Spiwok, V, Terashima, H, Accardi, A, Muller, D, Martinez-Cruz, L.A. 登録日 2014-02-27 公開日 2015-04-15 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4 To Be Published
4PCU	Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Ereno-Orbea, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez-Cruz, L.A. 登録日 2014-04-16 公開日 2014-09-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.578 Å) 主引用文献 Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine. Proc.Natl.Acad.Sci.USA, 111, 2014
4QFG	Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic activator 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-20 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
4QFR	Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor 分子名称: 2-chloro-4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-21 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
4QFS	Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor 分子名称: 2-bromo-3-(4-bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-21 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.55 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
4UUU	1.7 A resolution structure of human cystathionine beta-synthase regulatory domain (del 516-525) in complex with SAM 分子名称: 1,2-ETHANEDIOL, CYSTATHIONINE BETA-SYNTHASE, S-ADENOSYLMETHIONINE 著者 Kopec, J, McCorvie, T.J, Fitzpatrick, F, Strain-Damerell, C, Froese, D.S, Tallant, C, Burgess-Brown, N, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. 登録日 2014-07-31 公開日 2014-08-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation. J.Biol.Chem., 289, 2014
4RER	Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, ... 著者 Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. 登録日 2014-09-23 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.047 Å) 主引用文献 Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
4REW	Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. 登録日 2014-09-24 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.58 Å) 主引用文献 Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
5AHN	IMP-bound form of the D199N mutant of IMPDH from Pseudomonas aeruginosa 分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, MAGNESIUM ION 著者 Labesse, G, Alexandre, T, Gelin, M, Haouz, A, Munier-Lehmann, H. 登録日 2015-02-06 公開日 2015-07-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.652 Å) 主引用文献 Crystallographic Studies of Two Variants of Pseudomonas Aeruginosa Impdh with Impaired Allosteric Regulation Acta Crystallogr.,Sect.D, 71, 2015
4Z87	Structure of the IMP dehydrogenase from Ashbya gossypii bound to GDP 分子名称: ACETATE ION, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Buey, R.M, de Pereda, J.M, Revuelta, J.L. 登録日 2015-04-08 公開日 2015-11-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases. Nat Commun, 6, 2015
4ZHX	Novel binding site for allosteric activation of AMPK 分子名称: (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol, 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-2, ... 著者 Langendorf, C.G, Ngoei, K.R, Issa, S.M.A, Ling, N, Gorman, M.A, Parker, M.W, Sakamoto, K, Scott, J.W, Oakhill, J.S, Kemp, B.E. 登録日 2015-04-27 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun, 7, 2016
5AWE	Crystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-beta-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domains 分子名称: Putative acetoin utilization protein, acetoin dehydrogenase 著者 Nakabayashi, M, Shibata, N, Kanagawa, M, Nakagawa, N, Kuramitsu, S, Higuchi, Y. 登録日 2015-07-03 公開日 2016-05-18 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structure of a hypothetical protein, TTHA0829 from Thermus thermophilus HB8, composed of cystathionine-beta-synthase (CBS) and aspartate-kinase chorismate-mutase tyrA (ACT) domains. Extremophiles, 20, 2016
5EZV	X-ray crystal structure of AMP-activated protein kinase alpha-2/alpha-1 RIM chimaera (alpha-2(1-347)/alpha-1(349-401)/alpha-2(397-end) beta-1 gamma-1) co-crystallized with C2 (5-(5-hydroxyl-isoxazol-3-yl)-furan-2-phosphonic acid) 分子名称: 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-2/alpha-1 RIM SWAP chimera, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Langendorf, C.G, Kemp, B.E. 登録日 2015-11-26 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun, 7, 2016
5IIP	Staphylococcus aureus OpuCA 分子名称: Glycine betaine/carnitine/choline ABC transporter%2C ATP-binding protein%2C putative 著者 Tosi, T, Campeotto, I, Freemont, P.S, Grundling, A. 登録日 2016-03-01 公開日 2016-08-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The second messenger c-di-AMP inhibits the osmolyte uptake system OpuC in Staphylococcus aureus. Sci.Signal., 9, 2016
5ISO	STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991) 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Xiao, B, Hubbard, J.A, Gamblin, S.J. 登録日 2016-03-15 公開日 2017-03-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991) To Be Published
5K24	Crystal structure of the complex between phosphatase PRL-2 in the oxidized state with the Bateman domain of murine magnesium transporter CNNM3 分子名称: CITRATE ANION, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Gulerez, I, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K25	Crystal structure of human phosphatase PRL-2 in complex with the ADP-bound Bateman domain of human magnesium transporter CNNM3 分子名称: ADENOSINE-5'-DIPHOSPHATE, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K22	Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Wu, H, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. EMBO Rep., 17, 2016
5K23	Crystal structure of the complex between human phosphatase PRL-2 in the oxidized state with the Bateman domain of human magnesium transporter CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5G5R	CBS domain tandem of site-2 protease from Archaeoglobus fulgidus in complex with llama Nanobody - apo form 分子名称: NANOBODY, SITE-2 PROTEASE, SULFATE ION 著者 Schacherl, M, Baumann, U. 登録日 2016-06-02 公開日 2017-05-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease. Biochim. Biophys. Acta, 1859, 2017
5G5X	CBS domain tandem of site-2 protease from Archaeoglobus fulgidus in complex with llama Nanobody - nucleotide-bound form 分子名称: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, NANOBODY, ... 著者 Schacherl, M, Baumann, U. 登録日 2016-06-09 公開日 2017-05-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease. Biochim. Biophys. Acta, 1859, 2017
5KQ5	AMPK bound to allosteric activator 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2016-07-05 公開日 2016-08-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J.Med.Chem., 59, 2016

<123456789101112>