4COO

Crystal structure of human cystathionine beta-synthase (delta516-525) at 2.0 angstrom resolution

Summary for 4COO

DescriptorCYSTATHIONINE BETA-SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ... (8 entities in total)
Functional Keywordslyase, methionine cycle, metabolic pathway, allosteric regulation, serine metabolism
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm  P35520
Total number of polymer chains2
Total molecular weight127123.27
Authors
Primary citation
Mccorvie, T.J.,Kopec, J.,Hyung, S.,Fitzpatrick, F.,Feng, X.,Termine, D.,Strain-Damerell, C.,Vollmar, M.,Fleming, J.,Janz, J.M.,Bulawa, C.,Yue, W.W.
Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289:36018-, 2014
PubMed: 25336647 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M114.610782
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.208400.5%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report