4PCU
Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet
Summary for 4PCU
| Entry DOI | 10.2210/pdb4pcu/pdb |
| Related | 4L0D 4L27 4L28 4L3V |
| Descriptor | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total) |
| Functional Keywords | cbs domain, homocyteine, cysteine biosynthesis, heme, pyridoxal 5'-phosphate, s-adenosylmethionine, transsulfuration pathway, lyase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm : P35520 |
| Total number of polymer chains | 2 |
| Total formula weight | 123650.66 |
| Authors | Ereno-Orbea, J.,Majtan, T.,Oyenarte, I.,Kraus, J.P.,Martinez-Cruz, L.A. (deposition date: 2014-04-16, release date: 2014-09-24, Last modification date: 2023-12-27) |
| Primary citation | Ereno-Orbea, J.,Majtan, T.,Oyenarte, I.,Kraus, J.P.,Martinez-Cruz, L.A. Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine. Proc.Natl.Acad.Sci.USA, 111:E3845-E3852, 2014 Cited by PubMed: 25197074DOI: 10.1073/pnas.1414545111 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.578 Å) |
Structure validation
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