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4PCU

Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Cystathionine beta-synthasepolymer54960563.32UniProt (P35520)
Pfam (PF00291)
Pfam (PF00571)
Homo sapiens (Human)Beta-thionase, Serine sulfhydrase
2C, F
(A, B)
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.52Chemie (HEM)
3D, G
(A, B)
PYRIDOXAL-5'-PHOSPHATEnon-polymer247.12Chemie (PLP)
4E, H
(A, B)
S-ADENOSYLMETHIONINEnon-polymer398.42Chemie (SAM)
Sequence modifications
A, B: 1 - 551 (UniProt: P35520)
PDBExternal DatabaseDetails
Gly 2Pro 2conflict
Ser 201Glu 201engineered mutation
-Ile 516deletion
-Gln 517deletion
-Tyr 518deletion
-His 519deletion
-Ser 520deletion
-Thr 521deletion
-Gly 522deletion
-Lys 523deletion
-Ser 524deletion
-Ser 525deletion
Glu 552-expression tag
Leu 553-expression tag
His 554-expression tag
His 555-expression tag
His 556-expression tag
His 557-expression tag
His 558-expression tag
His 559-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight121126.5
Non-Polymers*Number of molecules6
Total formula weight2524.1
All*Total formula weight123650.7
*Water molecules are not included.

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PDB entries from 2025-07-16

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