4PCU

Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Cystathionine beta-synthase	polymer	549	60563.3	2	UniProt (P35520) Pfam (PF00291) Pfam (PF00571) In PDB	Homo sapiens (Human)	Beta-thionase, Serine sulfhydrase
2	A, B	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	A, B	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	2	Chemie (PLP)
4	A, B	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM)

Sequence modifications

A, B: 1 - 551 (UniProt: P35520)

PDB	External Database	Details
Gly 2	Pro 2	conflict
Ser 201	Glu 201	engineered mutation
-	Ile 516	deletion
-	Gln 517	deletion
-	Tyr 518	deletion
-	His 519	deletion
-	Ser 520	deletion
-	Thr 521	deletion
-	Gly 522	deletion
-	Lys 523	deletion
-	Ser 524	deletion
-	Ser 525	deletion
Glu 552	-	expression tag
Leu 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	121126.5
Non-Polymers*	Number of molecules	6
	Total formula weight	2524.1
All*	Total formula weight	123650.7

*Water molecules are not included.