4PCU
Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cystathionine beta-synthase | polymer | 549 | 60563.3 | 2 | UniProt (P35520) Pfam (PF00291) Pfam (PF00571) | Homo sapiens (Human) | Beta-thionase, Serine sulfhydrase |
| 2 | C, F (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, G (A, B) | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) PubChem (1051) | |||
| 4 | E, H (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (145712080) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (5136) PubChem (34755) PubChem (9865603) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) |
Sequence modifications
A, B: 1 - 551 (UniProt: P35520)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | Pro 2 | conflict |
| Ser 201 | Glu 201 | engineered mutation |
| - | Ile 516 | deletion |
| - | Gln 517 | deletion |
| - | Tyr 518 | deletion |
| - | His 519 | deletion |
| - | Ser 520 | deletion |
| - | Thr 521 | deletion |
| - | Gly 522 | deletion |
| - | Lys 523 | deletion |
| - | Ser 524 | deletion |
| - | Ser 525 | deletion |
| Glu 552 | - | expression tag |
| Leu 553 | - | expression tag |
| His 554 | - | expression tag |
| His 555 | - | expression tag |
| His 556 | - | expression tag |
| His 557 | - | expression tag |
| His 558 | - | expression tag |
| His 559 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 121126.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2524.1 | |
| All* | Total formula weight | 123650.7 |
