4Z87

Structure of the IMP dehydrogenase from Ashbya gossypii bound to GDP

Summary for 4Z87

Entry DOI	10.2210/pdb4z87/pdb
Descriptor	Inosine-5'-monophosphate dehydrogenase, GUANOSINE-5'-MONOPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	imp dehydrgoenase, bateman domain, oxidoreductase
Biological source	Ashbya gossypii (strain ATCC 10895)
Total number of polymer chains	4
Total formula weight	234398.66
Authors	Buey, R.M.,de Pereda, J.M.,Revuelta, J.L. (deposition date: 2015-04-08, release date: 2015-11-25, Last modification date: 2024-01-10)
Primary citation	Buey, R.M.,Ledesma-Amaro, R.,Velazquez-Campoy, A.,Balsera, M.,Chagoyen, M.,de Pereda, J.M.,Revuelta, J.L. Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases. Nat Commun, 6:8923-8923, 2015 Cited by PubMed: 26558346 DOI: 10.1038/ncomms9923 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation