Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003938 | molecular_function | IMP dehydrogenase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006183 | biological_process | GTP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003938 | molecular_function | IMP dehydrogenase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006164 | biological_process | purine nucleotide biosynthetic process |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006183 | biological_process | GTP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003938 | molecular_function | IMP dehydrogenase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006164 | biological_process | purine nucleotide biosynthetic process |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006183 | biological_process | GTP biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003938 | molecular_function | IMP dehydrogenase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006164 | biological_process | purine nucleotide biosynthetic process |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006183 | biological_process | GTP biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue 5GP A 601 |
| Chain | Residue |
| A | SER74 |
| A | GLY368 |
| A | GLY369 |
| A | MET388 |
| A | GLY390 |
| A | GLY391 |
| A | TYR414 |
| A | GLY416 |
| A | MET417 |
| A | GLY418 |
| A | SER419 |
| A | MET76 |
| A | GLN448 |
| A | GLY449 |
| A | HOH708 |
| A | HOH785 |
| A | ARG325 |
| A | GLY331 |
| A | SER332 |
| A | ILE333 |
| A | CYS334 |
| A | THR336 |
| A | ASP367 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue GDP A 602 |
| Chain | Residue |
| A | THR165 |
| A | SER166 |
| A | ASP168 |
| A | THR184 |
| A | ASP186 |
| A | VAL187 |
| A | ILE188 |
| A | LYS208 |
| A | GLY209 |
| A | HOH703 |
| A | HOH705 |
| A | HOH754 |
| A | HOH782 |
| A | HOH790 |
| A | HOH812 |
| B | ARG167 |
| B | LYS207 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue GDP A 603 |
| Chain | Residue |
| A | LYS115 |
| A | TYR116 |
| A | ASN118 |
| A | PRO124 |
| A | VAL125 |
| A | PHE145 |
| A | ALA146 |
| A | GLY147 |
| A | LYS210 |
| A | SER225 |
| A | THR227 |
| A | ASP228 |
| A | LYS231 |
| A | HOH742 |
| A | HOH773 |
| A | HOH775 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue GDP A 604 |
| Chain | Residue |
| A | GLU117 |
| A | ASN118 |
| A | GLY119 |
| A | LEU196 |
| A | GLU197 |
| A | ASN200 |
| A | ASP228 |
| A | LEU229 |
| A | ASN232 |
| A | LYS240 |
| A | LYS245 |
| A | HOH701 |
| D | THR8 |
| D | GLU11 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue K A 605 |
| Chain | Residue |
| A | GLY329 |
| A | GLY331 |
| A | CYS334 |
| A | GLU507 |
| A | GLY508 |
| A | GLY509 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 606 |
| Chain | Residue |
| A | SER58 |
| A | THR66 |
| A | ASN68 |
| D | ASP5 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | binding site for residue 5GP B 601 |
| Chain | Residue |
| B | HOH790 |
| B | SER74 |
| B | MET76 |
| B | ASN306 |
| B | ARG325 |
| B | GLY331 |
| B | SER332 |
| B | CYS334 |
| B | THR336 |
| B | ASP367 |
| B | GLY369 |
| B | MET388 |
| B | GLY390 |
| B | GLY391 |
| B | TYR414 |
| B | GLY416 |
| B | MET417 |
| B | GLY418 |
| B | GLN448 |
| B | HOH736 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for residue GDP B 602 |
| Chain | Residue |
| A | ARG167 |
| A | LYS207 |
| B | THR165 |
| B | SER166 |
| B | ARG167 |
| B | ASP168 |
| B | THR184 |
| B | ASP186 |
| B | VAL187 |
| B | ILE188 |
| B | LYS208 |
| B | GLY209 |
| B | HOH734 |
| B | HOH743 |
| B | HOH764 |
| B | HOH783 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | binding site for residue GDP B 603 |
| Chain | Residue |
| B | LYS115 |
| B | TYR116 |
| B | ASN118 |
| B | PRO124 |
| B | VAL125 |
| B | PHE145 |
| B | ALA146 |
| B | GLY147 |
| B | LYS210 |
| B | SER225 |
| B | THR227 |
| B | ASP228 |
| B | LYS231 |
| B | HOH709 |
| B | HOH711 |
| B | HOH727 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue GDP B 604 |
| Chain | Residue |
| B | GLU117 |
| B | ASN118 |
| B | GLY119 |
| B | ASN200 |
| B | ASP228 |
| B | LEU229 |
| B | ASN232 |
| B | PRO236 |
| B | LYS240 |
| B | LYS245 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue K B 605 |
| Chain | Residue |
| B | GLY329 |
| B | GLY331 |
| B | CYS334 |
| B | GLU507 |
| B | GLY508 |
| B | GLY509 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue ACT B 606 |
| Chain | Residue |
| B | LEU91 |
| B | ILE464 |
| site_id | AD4 |
| Number of Residues | 23 |
| Details | binding site for residue 5GP C 601 |
| Chain | Residue |
| C | SER74 |
| C | MET76 |
| C | ASN306 |
| C | ARG325 |
| C | GLY331 |
| C | SER332 |
| C | ILE333 |
| C | CYS334 |
| C | THR336 |
| C | ASP367 |
| C | GLY369 |
| C | MET388 |
| C | GLY390 |
| C | GLY391 |
| C | TYR414 |
| C | GLY416 |
| C | MET417 |
| C | GLY418 |
| C | GLN448 |
| C | GLY449 |
| C | ACT606 |
| C | HOH738 |
| C | HOH746 |
| site_id | AD5 |
| Number of Residues | 11 |
| Details | binding site for residue GDP C 602 |
| Chain | Residue |
| C | THR165 |
| C | SER166 |
| C | ASP168 |
| C | THR184 |
| C | ASP186 |
| C | VAL187 |
| C | ILE188 |
| C | LYS208 |
| C | GLY209 |
| D | ARG167 |
| D | LYS207 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue GDP C 603 |
| Chain | Residue |
| C | LYS115 |
| C | TYR116 |
| C | ASN118 |
| C | ILE121 |
| C | PRO124 |
| C | VAL125 |
| C | PHE145 |
| C | ALA146 |
| C | GLY147 |
| C | LYS210 |
| C | SER225 |
| C | THR227 |
| C | ASP228 |
| C | LYS231 |
| C | HOH712 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue GDP C 604 |
| Chain | Residue |
| B | ALA7 |
| B | GLU11 |
| B | HIS318 |
| C | GLU117 |
| C | ASN118 |
| C | GLY119 |
| C | LEU196 |
| C | ASN200 |
| C | ASP228 |
| C | LEU229 |
| C | ASN232 |
| C | LYS240 |
| C | LYS245 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue K C 605 |
| Chain | Residue |
| C | GLY329 |
| C | GLY331 |
| C | CYS334 |
| C | GLU507 |
| C | GLY508 |
| C | GLY509 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue ACT C 606 |
| Chain | Residue |
| C | ASP277 |
| C | SER278 |
| C | ARG325 |
| C | 5GP601 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue ACT C 607 |
| Chain | Residue |
| C | LEU91 |
| C | TYR468 |
| site_id | AE2 |
| Number of Residues | 21 |
| Details | binding site for residue 5GP D 600 |
| Chain | Residue |
| D | SER74 |
| D | MET76 |
| D | ARG325 |
| D | GLY331 |
| D | SER332 |
| D | ILE333 |
| D | CYS334 |
| D | THR336 |
| D | ASP367 |
| D | GLY369 |
| D | MET388 |
| D | GLY390 |
| D | GLY391 |
| D | TYR414 |
| D | GLY416 |
| D | MET417 |
| D | GLY418 |
| D | GLN448 |
| D | GLY449 |
| D | HOH712 |
| D | HOH739 |
| site_id | AE3 |
| Number of Residues | 14 |
| Details | binding site for residue GDP D 601 |
| Chain | Residue |
| C | ARG167 |
| C | LYS207 |
| D | THR165 |
| D | SER166 |
| D | ARG167 |
| D | ASP168 |
| D | THR184 |
| D | ASP186 |
| D | VAL187 |
| D | ILE188 |
| D | LYS208 |
| D | GLY209 |
| D | HOH701 |
| D | HOH758 |
| site_id | AE4 |
| Number of Residues | 14 |
| Details | binding site for residue GDP D 602 |
| Chain | Residue |
| D | LYS115 |
| D | TYR116 |
| D | ASN118 |
| D | PRO124 |
| D | VAL125 |
| D | PHE145 |
| D | ALA146 |
| D | GLY147 |
| D | LYS210 |
| D | SER225 |
| D | THR227 |
| D | ASP228 |
| D | LYS231 |
| D | HOH758 |
| site_id | AE5 |
| Number of Residues | 9 |
| Details | binding site for residue GDP D 603 |
| Chain | Residue |
| D | GLU117 |
| D | ASN118 |
| D | GLY119 |
| D | ASN200 |
| D | ASP228 |
| D | ASN232 |
| D | LYS240 |
| D | LYS245 |
| D | HOH711 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue K D 604 |
| Chain | Residue |
| D | GLY329 |
| D | GLY331 |
| D | CYS334 |
| D | GLU507 |
| D | GLY508 |
| D | GLY509 |
Functional Information from PROSITE/UniProt
| site_id | PS00487 |
| Number of Residues | 13 |
| Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRIGMGsGSICiT |
| Chain | Residue | Details |
| A | LEU324-THR336 | |
