4UUU

1.7 A resolution structure of human cystathionine beta-synthase regulatory domain (del 516-525) in complex with SAM

Summary for 4UUU

DescriptorCYSTATHIONINE BETA-SYNTHASE, S-ADENOSYLMETHIONINE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordslyase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm  P35520
Total number of polymer chains2
Total molecular weight36436.01
Authors
Kopec, J.,McCorvie, T.J.,Fitzpatrick, F.,Strain-Damerell, C.,Froese, D.S.,Tallant, C.,Burgess-Brown, N.,Arrowsmith, C.,Edwards, A.,Bountra, C.,Yue, W.W. (deposition date: 2014-07-31, release date: 2014-08-13, Last modification date: 2015-01-14)
Primary citation
Mccorvie, T.J.,Kopec, J.,Hyung, S.,Fitzpatrick, F.,Feng, X.,Termine, D.,Strain-Damerell, C.,Vollmar, M.,Fleming, J.,Janz, J.M.,Bulawa, C.,Yue, W.W.
Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289:36018-, 2014
PubMed: 25336647 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M114.610782
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.71 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2075 0.4%0 1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
170172
PDB entries from 2020-10-21