PDB: 285 件ウェブページステータス検索Chemie searchBIRD

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6B1U	Structure of full-length human AMPK (a2b1g1) in complex with a small molecule activator SC4 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Ngoei, K.R.W, Langendorf, C.G, Ling, N.X.Y, Hoque, A, Johnson, S, Camerino, M.C, Walker, S.R, Bozikis, Y.E, Dite, T.A, Ovens, A.J, Smiles, W.J, Jacobs, R, Huang, H, Parker, M.W, Scott, J.W, Rider, M.H, Kemp, B.E, Foitzik, R.C, Baell, J.B, Oakhill, J.S. 登録日 2017-09-19 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4. Cell Chem Biol, 25, 2018
6C9J	AMP-activated protein kinase bound to pharmacological activator R734 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Brunzelle, J.S, Hitoshi, Y, Griffin, P.R, Xu, H.E, Melcher, K. 登録日 2018-01-26 公開日 2018-11-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
6C9G	AMP-activated protein kinase bound to pharmacological activator R739 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K. 登録日 2018-01-26 公開日 2018-11-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
5K24	Crystal structure of the complex between phosphatase PRL-2 in the oxidized state with the Bateman domain of murine magnesium transporter CNNM3 分子名称: CITRATE ANION, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Gulerez, I, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K25	Crystal structure of human phosphatase PRL-2 in complex with the ADP-bound Bateman domain of human magnesium transporter CNNM3 分子名称: ADENOSINE-5'-DIPHOSPHATE, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K22	Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Wu, H, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. EMBO Rep., 17, 2016
5K23	Crystal structure of the complex between human phosphatase PRL-2 in the oxidized state with the Bateman domain of human magnesium transporter CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5KQ5	AMPK bound to allosteric activator 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2016-07-05 公開日 2016-08-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J.Med.Chem., 59, 2016
5MCP	Structure of IMP dehydrogenase from Ashbya gossypii bound to ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, MAGNESIUM ION 著者 Winter, G, Fernandez-Justel, D, de Pereda, J.M, Revuelta, J.L, Buey, R.M. 登録日 2016-11-10 公開日 2017-06-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases. Sci Rep, 7, 2017
4L3V	Crystal structure of delta516-525 human cystathionine beta-synthase 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE 著者 Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. 登録日 2013-06-07 公開日 2013-09-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.628 Å) 主引用文献 Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
4L27	Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE 著者 Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. 登録日 2013-06-04 公開日 2013-09-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.391 Å) 主引用文献 Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
4L28	Crystal structure of delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE 著者 Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. 登録日 2013-06-04 公開日 2013-09-18 最終更新日 2013-10-16 実験手法 X-RAY DIFFRACTION (2.626 Å) 主引用文献 Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
4L0D	Crystal structure of delta516-525 human cystathionine beta-synthase containing C-terminal 6xHis-tag 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE 著者 Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez-Cruz, L.A. 登録日 2013-05-31 公開日 2013-09-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
4PCU	Crystal structure of delta516-525 E201S human cystathionine beta-synthase with AdoMet 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... 著者 Ereno-Orbea, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez-Cruz, L.A. 登録日 2014-04-16 公開日 2014-09-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.578 Å) 主引用文献 Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine. Proc.Natl.Acad.Sci.USA, 111, 2014
4QFG	Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic activator 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-20 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
4QFR	Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor 分子名称: 2-chloro-4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-21 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
4QFS	Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor 分子名称: 2-bromo-3-(4-bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2014-05-21 公開日 2014-08-06 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (3.55 Å) 主引用文献 Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms. Structure, 22, 2014
4RER	Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, ... 著者 Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. 登録日 2014-09-23 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.047 Å) 主引用文献 Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
4REW	Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K. 登録日 2014-09-24 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (4.58 Å) 主引用文献 Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Res., 25, 2015
1JCN	BINARY COMPLEX OF HUMAN TYPE-I INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP 分子名称: 6-CHLOROPURINE RIBOSIDE, 5'-MONOPHOSPHATE, INOSINE MONOPHOSPHATE DEHYDROGENASE I 著者 Risal, D, Strickler, M.D, Goldstein, B.M. 登録日 2001-06-11 公開日 2003-06-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of the Human Type I Inosine Monophosphate Dehydrogenase and Implications for Isoform Specificity To be Published
1JR1	Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid 分子名称: INOSINIC ACID, Inosine-5'-Monophosphate Dehydrogenase 2, MYCOPHENOLIC ACID, ... 著者 Sintchak, M.D, Fleming, M.A, Futer, O, Raybuck, S.A, Chambers, S.P, Caron, P.R, Murcko, M.A, Wilson, K.P. 登録日 2001-08-09 公開日 2001-09-05 最終更新日 2017-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell(Cambridge,Mass.), 85, 1996
8S5M	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, SAM bound, activated state, helical reconstruction 分子名称: Cystathionine beta-synthase, S-ADENOSYLMETHIONINE 著者 McCorvie, T.J, Yue, W.W. 登録日 2024-02-23 公開日 2024-04-17 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5L	Full-length human cystathionine beta-synthase, basal state, partially degraded tetramer 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE 著者 McCorvie, T.J, Yue, W.W. 登録日 2024-02-23 公開日 2024-04-17 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5J	Full-length human cystathionine beta-synthase, basal state, helical reconstruction 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE 著者 McCorvie, T.J, Yue, W.W. 登録日 2024-02-23 公開日 2024-04-17 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024
8S5H	Full-length human cystathionine beta-synthase with C-terminal 6xHis-tag, basal state, helical reconstruction 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE 著者 McCorvie, T.J, Yue, W.W. 登録日 2024-02-23 公開日 2024-04-17 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Architecture and regulation of filamentous human cystathionine beta-synthase. Nat Commun, 15, 2024

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