1JR1
Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid
Summary for 1JR1
Entry DOI | 10.2210/pdb1jr1/pdb |
Related | 1AK5 1B3O 1ZFJ |
Descriptor | Inosine-5'-Monophosphate Dehydrogenase 2, POTASSIUM ION, INOSINIC ACID, ... (5 entities in total) |
Functional Keywords | dehydrogenase, impd, impdh, guanine nucleotide synthesis, mycophenolic acid, mpa, oxidoreductase |
Biological source | Cricetulus griseus (Chinese hamster) |
Cellular location | Cytoplasm : P12269 |
Total number of polymer chains | 2 |
Total formula weight | 113337.45 |
Authors | Sintchak, M.D.,Fleming, M.A.,Futer, O.,Raybuck, S.A.,Chambers, S.P.,Caron, P.R.,Murcko, M.A.,Wilson, K.P. (deposition date: 2001-08-09, release date: 2001-09-05, Last modification date: 2017-10-04) |
Primary citation | Sintchak, M.D.,Fleming, M.A.,Futer, O.,Raybuck, S.A.,Chambers, S.P.,Caron, P.R.,Murcko, M.A.,Wilson, K.P. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Cell(Cambridge,Mass.), 85:921-930, 1996 Cited by PubMed: 8681386DOI: 10.1016/S0092-8674(00)81275-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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