PDB: 294 件ウェブページステータス検索Chemie searchBIRD

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5KA6	HIV-1 gp41 variant Q552R and L555M resistance mutations 分子名称: Transmembrane protein gp41 著者 Bhardwaj, A, Khasnis, M.D, Halkidis, K, Root, M.J. 登録日 2016-06-01 公開日 2016-12-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer. PLoS Pathog., 12, 2016
5THR	Cryo-EM structure of a BG505 Env-sCD4-17b-8ANC195 complex 分子名称: 17b Fab VH domain, 17b Fab VL domain, 8ANC195 G52K5 VH domain, ... 著者 Wang, H, Bjorkman, P.J. 登録日 2016-09-30 公開日 2016-11-16 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (8.9 Å) 主引用文献 Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc.Natl.Acad.Sci.USA, 113, 2016
5T3Z	3.5 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074 分子名称: 10-1074 Heavy Chain, 10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gristick, H.B, Bjorkman, P.J. 登録日 2016-08-26 公開日 2016-10-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat.Struct.Mol.Biol., 23, 2016
5T3X	3.9 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074. 分子名称: 10-1074 Heavy Chain, 10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gristick, H.B, Bjorkman, P.J. 登録日 2016-08-26 公開日 2016-10-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.9 Å) 主引用文献 Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site. Nat.Struct.Mol.Biol., 23, 2016
5T3S	HIV gp140 trimer MD39-10MUTA in complex with Fabs PGT124 and 35022 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Stanfield, R.L, Wilson, I.A. 登録日 2016-08-26 公開日 2016-09-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies. Immunity, 45, 2016
5D9Q	Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 and scFv NIH45-46 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... 著者 Julien, J.-P, Stanfield, R.L, Ward, A.B, Wilson, I.A. 登録日 2015-08-18 公開日 2016-08-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.4 Å) 主引用文献 Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design. Plos Pathog., 12, 2016
5JS9	Uncleaved prefusion optimized gp140 trimer with an engineered 8-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kong, L, Wilson, I.A. 登録日 2016-05-07 公開日 2016-07-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (6.918 Å) 主引用文献 Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nat Commun, 7, 2016
5JSA	Uncleaved prefusion optimized gp140 trimer with an engineered 10-residue HR1 turn bound to broadly neutralizing antibodies 8ANC195 and PGT128 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kong, L, Wilson, I.A. 登録日 2016-05-07 公開日 2016-07-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (6.308 Å) 主引用文献 Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nat Commun, 7, 2016
5I8H	Crystal Structure of HIV-1 BG505 SOSIP.664 Prefusion Env Trimer in Complex with V3 Loop-targeting Antibody PGT122 Fab and Fusion Peptide-targeting Antibody VRC34.01 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP.664 gp120, ... 著者 Xu, K, Zhou, T, Kwong, P.D. 登録日 2016-02-18 公開日 2016-05-25 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (4.301 Å) 主引用文献 Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody. Science, 352, 2016
5FYL	Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 ANTIBODY FAB HEAVY CHAIN, ... 著者 Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. 登録日 2016-03-08 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
5FYJ	Crystal Structure at 3.4 A Resolution of Fully Glycosylated HIV-1 Clade G X1193.c1 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. 登録日 2016-03-08 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
5FYK	Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade B JR-FL SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22, ... 著者 Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D. 登録日 2016-03-08 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.107 Å) 主引用文献 Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G Cell(Cambridge,Mass.), 165, 2016
5FUU	Ectodomain of cleaved wild type JR-FL EnvdCT trimer in complex with PGT151 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lee, J.H, Ward, A.B. 登録日 2016-01-29 公開日 2016-03-09 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-Em Structure of a Native, Fully Glycosylated and Cleaved HIV-1 Envelope Trimer Science, 351, 2016
5CEZ	Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with an early putative precursor of the PGT121 family at 3.0 Angstrom 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35022 Fab Heavy Chain, ... 著者 Wilson, I.A, Garces, F. 登録日 2015-07-08 公開日 2015-12-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.031 Å) 主引用文献 Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity, 43, 2015
5C7K	Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab 8ANC195 heavy chain, ... 著者 Kong, L, Stanfield, R.L, Wilson, I.A. 登録日 2015-06-24 公開日 2015-10-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.6019 Å) 主引用文献 Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer. Acta Crystallogr.,Sect.D, 71, 2015
5ACO	Cryo-EM structure of PGT128 Fab in complex with BG505 SOSIP.664 Env trimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 ENVELOPE GLYCOPROTEIN, ... 著者 Lee, J.H, Ward, A.B. 登録日 2015-08-17 公開日 2015-09-30 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy. Structure, 23, 2015
5CJX	Crystal structure of 8ANC195 Fab in complex with BG505 SOSIP.664 HIV-1 Env trimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8ANC195 G52K5 heavy chain, ... 著者 Scharf, L, Bjorkman, P.J. 登録日 2015-07-15 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.584 Å) 主引用文献 Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env. Cell, 162, 2015
4ZMJ	Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... 著者 Kwon, Y.D, Kwong, P.D. 登録日 2015-05-04 公開日 2015-06-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env. Nat.Struct.Mol.Biol., 22, 2015
4TVP	Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ... 著者 Pancera, M, Zhou, T, Kwong, P.D. 登録日 2014-06-27 公開日 2014-10-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure and immune recognition of trimeric pre-fusion HIV-1 Env. Nature, 514, 2014
4KHT	Triple helix bundle of GP41 complexed with fab 8066 分子名称: 8066 heavy chain, 8066 light chain, Gp41 helix 著者 Li, M, Gustchina, A, Wlodawer, A. 登録日 2013-05-01 公開日 2014-03-12 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.817 Å) 主引用文献 Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41. Plos One, 8, 2013
4KHX	Crystal structure of gp41 helix complexed with antibody 8062 分子名称: 8062 heavy chain, 8062 light chain, gp41 helix 著者 Li, M, Gustchina, A, Wlodawer, A. 登録日 2013-05-01 公開日 2014-03-12 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.921 Å) 主引用文献 Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41. Plos One, 8, 2013
3WFV	HIV-1 CRF07 gp41 分子名称: Envelope glycoprotein gp160 著者 Du, J, Xue, H, Ma, J, Liu, F, Zhou, J, Shao, Y, Qiao, W, Liu, X. 登録日 2013-07-24 公開日 2013-10-16 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat Virology, 446, 2013
2XRA	crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix 分子名称: HK20, HUMAN MONOCLONAL ANTIBODY HEAVY CHAIN, HUMAN MONOCLONAL ANTIBODY LIGHT CHAIN, ... 著者 Sabin, C, Corti, D, Buzon, V, Seaman, M.S, Lutje Hulsik, D, Hinz, A, Vanzetta, F, Agatic, G, Silacci, C, Langedijk, J.P.M, Mainetti, L, Scarlatti, G, Sallusto, F, Weiss, R, Lanzavecchia, A, Weissenhorn, W. 登録日 2010-09-13 公開日 2010-12-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41. PLoS Pathog., 6, 2010
3CYO	Structure of a longer thermalstable core domain of HIV-1 GP41 containing the enfuvirtide resistance mutation N43D and complementary mutation E137K 分子名称: Transmembrane protein 著者 Wang, Z.M, Dwyer, J.J. 登録日 2008-04-25 公開日 2008-06-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure. Biochemistry, 47, 2008
2OT5	Crystal structure of the HIV gp41 core with the enfuvirtide resistance mutation N43D 分子名称: HIV-1 gp41 glycoprotein 著者 Bai, X, Seedorff, J.E, Green, J, Dwyer, J.J. 登録日 2007-02-07 公開日 2008-06-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure. Biochemistry, 47, 2008

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