5T3Z

3.5 Angstrom Crystal Structure of a Fully and Natively Glycosylated BG505 SOSIP.664 HIV-1 Env Trimer in Complex with the Broadly Neutralizing Antibodies IOMA and 10-1074

Summary for 5T3Z

• Entry DOI: 10.2210/pdb5t3z/pdb
• Related: 5T3X
• Descriptor: Envelope glycoprotein gp160, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)]alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (19 entities in total)
• Functional Keywords: hiv, n-linked glycosylation, broadly neutralizing antibodies, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 6
• Total formula weight: 184254.60

Authors

Gristick, H.B.,Bjorkman, P.J. (deposition date: 2016-08-26, release date: 2016-10-05, Last modification date: 2023-10-04)

• Primary citation: Gristick, H.B.,von Boehmer, L.,West, A.P.,Schamber, M.,Gazumyan, A.,Golijanin, J.,Seaman, M.S.,Fatkenheuer, G.,Klein, F.,Nussenzweig, M.C.,Bjorkman, P.J.; Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site.; Nat.Struct.Mol.Biol., 23:906-915, 2016; PubMed: 27617431; DOI: 10.1038/nsmb.3291

Experimental method

X-RAY DIFFRACTION (3.5 Å)