2XRA

crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix

Summary for 2XRA

Related1DF4 1DF5 1DLB 1OPN 1OPW 1GC1 1OPT 1K33 1RZJ 1G9M 1K34 1AIK 2CMR 1GZL 1MZI
DescriptorTRANSMEMBRANE PROTEIN GP41, HK20, HUMAN MONOCLONAL ANTIBODY HEAVY CHAIN, HK20, HUMAN MONOCLONAL ANTIBODY LIGHT CHAIN, ... (4 entities in total)
Functional Keywordsimmune system, antibody, monoclonal cells, neutralization tests
Biological sourceSYNTHETIC CONSTRUCT
More
Cellular locationSurface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein  P04578
Total number of polymer chains3
Total molecular weight72961.45
Authors
Primary citation
Sabin, C.,Corti, D.,Buzon, V.,Seaman, M.S.,Lutje Hulsik, D.,Hinz, A.,Vanzetta, F.,Agatic, G.,Silacci, C.,Mainetti, L.,Scarlatti, G.,Sallusto, F.,Weiss, R.,Lanzavecchia, A.,Weissenhorn, W.
Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.
PLoS Pathog., 6:e1001195-e1001195, 2010
PubMed: 21124990 (PDB entries with the same primary citation)
DOI: 10.1371/journal.ppat.1001195
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27561.0%2.0%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2xra
no rotation
Molmil generated image of 2xra
rotated about x axis by 90°
Molmil generated image of 2xra
rotated about y axis by 90°