2CMR

Crystal structure of the HIV-1 neutralizing antibody D5 Fab bound to the gp41 inner-core mimetic 5-helix

Summary for 2CMR

Entry DOI	10.2210/pdb2cmr/pdb
Related	1AIK 1DF4 1DF5 1DLB 1G9M 1GC1 1GZL 1K33 1K34 1MZI 1OPN 1OPT 1OPW 1RZJ
Descriptor	TRANSMEMBRANE GLYCOPROTEIN, D5, GLYCEROL, ... (5 entities in total)
Functional Keywords	immune system, immunoglobulin complex, neutralization, immunoglobulin, envelope protein, hiv, gp41, aids, mhc i, membrane, transmembrane, immunoglobulin domain
Biological source	HUMAN IMMUNODEFICIENCY VIRUS 1 More
Total number of polymer chains	3
Total formula weight	71017.23
Authors	Luftig, M.A.,Mattu, M.,Di Giovine, P.,Geleziunas, R.,Hrin, R.,Barbato, G.,Bianchi, E.,Miller, M.D.,Pessi, A.,Carfi, A. (deposition date: 2006-05-11, release date: 2006-10-16, Last modification date: 2023-12-13)
Primary citation	Luftig, M.A.,Mattu, M.,Di Giovine, P.,Geleziunas, R.,Hrin, R.,Barbato, G.,Bianchi, E.,Miller, M.D.,Pessi, A.,Carfi, A. Structural Basis for HIV-1 Neutralization by a Gp41 Fusion Intermediate-Directed Antibody Nat.Struct.Mol.Biol., 13:740-, 2006 Cited by PubMed: 16862157 DOI: 10.1038/NSMB1127 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation