2CMR
Crystal structure of the HIV-1 neutralizing antibody D5 Fab bound to the gp41 inner-core mimetic 5-helix
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TRANSMEMBRANE GLYCOPROTEIN | polymer | 226 | 25479.5 | 1 | UniProt (P04578) Pfam (PF00517) | HUMAN IMMUNODEFICIENCY VIRUS 1 | GP41 |
| 2 | B (H) | D5 | polymer | 217 | 22756.4 | 1 | HOMO SAPIENS (HUMAN) | FAB HEAVY CHAIN | |
| 3 | C (L) | D5 | polymer | 208 | 22689.2 | 1 | HOMO SAPIENS (HUMAN) | FAB LIGHT CHAIN | |
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F, G (A, H, L) | water | water | 18.0 | 283 | Chemie (HOH) |
Sequence modifications
A: 1 - 1 (PDB: 2CMR)
A: 218 - 226 (PDB: 2CMR)
A: 42 - 46 (PDB: 2CMR)
A: 85 - 89 (PDB: 2CMR)
A: 130 - 134 (PDB: 2CMR)
A: 173 - 177 (PDB: 2CMR)
A: 178 - 217 (UniProt: P04578)
A: 2 - 41 (UniProt: P04578)
A: 47 - 84 (UniProt: P04578)
A: 90 - 129 (UniProt: P04578)
A: 135 - 172 (UniProt: P04578)
A: 218 - 226 (PDB: 2CMR)
A: 42 - 46 (PDB: 2CMR)
A: 85 - 89 (PDB: 2CMR)
A: 130 - 134 (PDB: 2CMR)
A: 173 - 177 (PDB: 2CMR)
A: 178 - 217 (UniProt: P04578)
A: 2 - 41 (UniProt: P04578)
A: 47 - 84 (UniProt: P04578)
A: 90 - 129 (UniProt: P04578)
A: 135 - 172 (UniProt: P04578)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70925.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 71017.2 |
