3CYO

Structure of a longer thermalstable core domain of HIV-1 GP41 containing the enfuvirtide resistance mutation N43D and complementary mutation E137K

Summary for 3CYO

• Entry DOI: 10.2210/pdb3cyo/pdb
• Related: 3CP1
• Descriptor: Transmembrane protein (2 entities in total)
• Functional Keywords: hiv-1 envelope glycoprotein, 6-helix bundle, gp41, n43d, e137k, aids, apoptosis, coiled coil, envelope protein, fusion protein, host-virus interaction, membrane, transmembrane, virion, viral protein, cleavage on pair of basic residues, lipoprotein, palmitate, viral immunoevasion
• Biological source: Human immunodeficiency virus type 1; More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: Q70626
• Total number of polymer chains: 1
• Total formula weight: 9975.19

Authors

Wang, Z.M.,Dwyer, J.J. (deposition date: 2008-04-25, release date: 2008-06-17, Last modification date: 2023-08-30)

• Primary citation: Bai, X.,Wilson, K.L.,Seedorff, J.E.,Ahrens, D.,Green, J.,Davison, D.K.,Jin, L.,Stanfield-Oakley, S.A.,Mosier, S.M.,Melby, T.E.,Cammack, N.,Wang, Z.,Greenberg, M.L.,Dwyer, J.J.; Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure.; Biochemistry, 47:6662-6670, 2008; PubMed: 18507398; DOI: 10.1021/bi702509d

Experimental method

X-RAY DIFFRACTION (2.1 Å)