3CYO

Structure of a longer thermalstable core domain of HIV-1 GP41 containing the enfuvirtide resistance mutation N43D and complementary mutation E137K

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Transmembrane protein	polymer	86	9975.2	1	UniProt (Q70626) Pfam (PF00517)	Human immunodeficiency virus type 1	TM, GLYCOPROTEIN41, GP41
2	B (A)	water	water		18.0	27	Chemie (HOH)

Sequence modifications

A: 1 - 44 (UniProt: Q70626)

PDB	External Database	Details
Asp 19	Asn 554	engineered mutation

A: 51 - 86 (UniProt: Q70626)

PDB	External Database	Details
Ser 45	-	linker
Gly 46	-	linker
Gly 47	-	linker
Arg 48	-	linker
Gly 49	-	linker
Gly 50	-	linker
Lys 71	Glu 648	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	9975.2
All*	Total formula weight	9975.2

*Water molecules are not included.