PDB: 76 件ウェブページステータス検索Chemie searchBIRD

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3E2T	The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan 分子名称: FE (III) ION, IMIDAZOLE, SULFATE ION, ... 著者 Windahl, M.S, Petersen, C.R, Christensen, H.E.C, Harris, P. 登録日 2008-08-06 公開日 2008-11-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of tryptophan hydroxylase with bound amino acid substrate Biochemistry, 47, 2008
3HFB	Crystal structure of human tryoptophan hydroxylase type 1 with LP-534193 分子名称: 4-(5-{[(2'-methylbiphenyl-2-yl)methyl]amino}pyrazin-2-yl)-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Tari, L.W, Swanson, R.V, Hunter, M.J. 登録日 2009-05-11 公開日 2010-04-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4, 2010
3HF6	Crystal structure of human tryptophan hydroxylase type 1 with bound LP-521834 and FE 分子名称: 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Tari, L.W, Swanson, R.V, Hunter, M.J. 登録日 2009-05-11 公開日 2009-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis Curr Chem Genomics, 4, 2010
3HF8	Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe 分子名称: 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Tari, L.W, Swanson, R.V, Hunter, M.J. 登録日 2009-05-11 公開日 2010-04-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4, 2010
2XSN	Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain 分子名称: TYROSINE 3-MONOOXYGENASE, ZINC ION 著者 Muniz, J.R.C, Cooper, C.D.O, Yue, W.W, Krysztofinska, E, von Delft, F, Knapp, S, Gileadi, O, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Kavanagh, K.L, Oppermann, U. 登録日 2010-10-29 公開日 2010-11-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain To be Published
3TCY	Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum (cPAH) bound to phenylalanine in a site distal to the active site 分子名称: 1,2-ETHANEDIOL, COBALT (II) ION, PHENYLALANINE, ... 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2011-08-09 公開日 2012-08-22 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
3TK2	Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum cocrystallized with phenylalanine in a site distal to the active site 分子名称: COBALT (II) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2011-08-25 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
3TK4	Crystal structure of phenylalanine hydroxylase from Chromobacterium violaceum bound to cobalt 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2011-08-25 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
4ANP	Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone 分子名称: 5,6-DIMETHYL-3-(4-METHYL-2-PYRIDINYL)-2-THIOXO-2,3-DIHYDROTHIENO[2,3- D]PYRIMIDIN-4(1H)-ONE, FE (III) ION, PHENYLALANINE-4-HYDROXYLASE 著者 Torreblanca, R, Lira-Navarrete, E, Sancho, J, Hurtado-Guerrero, R. 登録日 2012-03-21 公開日 2012-04-11 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Structural and Mechanistic Basis of the Interaction between a Pharmacological Chaperone and Human Phenylalanine Hydroxylase. Chembiochem, 13, 2012
4ESM	Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum Y155A mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Paul, L.P, Corn, I.R, Wagner, K.T, Abu-Omar, M.M, Das, C. 登録日 2012-04-23 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
4ETL	Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum F258A mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Paul, L.P, Corn, I.R, Wagner, K.T, Abu-Omar, M.M, Das, C. 登録日 2012-04-24 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
4JPY	Iron and phenylalanine bound crystal structure of phenylalanine hydroxylase from Chromobacterium violaceum 分子名称: FE (III) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2013-03-19 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
4JPX	Crystal structure of phenylalanine hydroxylase S203P mutant from Chromobacterium violaceum 分子名称: COBALT (II) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2013-03-19 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
4BPT	Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila 分子名称: DI(HYDROXYETHYL)ETHER, PHENYLALANINE-4-HYDROXYLASE (PAH) (PHE-4-MONOOXYGENASE) 著者 Leiros, H.-K.S, Flydal, M.I, Martinez, A. 登録日 2013-05-28 公開日 2013-08-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and Thermodynamic Insight Into Phenylalanine Hydroxylase from the Human Pathogen Legionella Pneumophila. FEBS Open Bio, 3, 2013
4Q3Y	Crystal structure of C. violaceum phenylalanine hydroxylase D139A mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
4Q3Z	Crystal structure of C. violaceum phenylalanine hydroxylase D139K mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
4Q3W	Crystal structure of C. violaceum phenylalanine hydroxylase D139E mutation 分子名称: 1,2-ETHANEDIOL, COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
4Q3X	Crystal structure of C. violaceum phenylalanine hydroxylase D139N mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
4V06	Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain 分子名称: FE (III) ION, IMIDAZOLE, TRYPTOPHAN 5-HYDROXYLASE 2 著者 Kopec, J, Oberholzer, A, Fitzpatrick, F, Newman, J, Tallant, C, Kiyani, W, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. 登録日 2014-09-11 公開日 2014-10-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain To be Published
5DEN	The First Structure of a Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of an Auto-inhibited Tetramer 分子名称: FE (III) ION, Phenylalanine-4-hydroxylase 著者 Arturo, E.C, Loll, P.J, Jaffe, E.K. 登録日 2015-08-25 公開日 2016-02-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proc.Natl.Acad.Sci.USA, 113, 2016
5EGQ	Structure of tetrameric rat phenylalanine hydroxylase mutant R270K, residues 25-453 分子名称: Phenylalanine-4-hydroxylase, SULFATE ION 著者 Taylor, A.B, Khan, C.A, Fitzpatrick, P.F. 登録日 2015-10-27 公開日 2016-05-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering. J.Am.Chem.Soc., 138, 2016
5FGJ	Structure of tetrameric rat phenylalanine hydroxylase, residues 1-453 分子名称: FE (III) ION, MAGNESIUM ION, Phenylalanine-4-hydroxylase 著者 Taylor, A.B, Roberts, K.M, Fitzpatrick, P.F. 登録日 2015-12-20 公開日 2016-05-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering. J.Am.Chem.Soc., 138, 2016
5J6D	Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[(N-{[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl}carbamimidoyl)carbamoyl]-L-phenylalanine, FE (III) ION, ... 著者 Stein, A.J, Goldberg, D.R, De Lombaert, S. 登録日 2016-04-04 公開日 2016-05-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
5JK8	Phenylalanine hydroxylase from dictyostelium - BH2, norleucine complex 分子名称: 7,8-DIHYDROBIOPTERIN, FE (III) ION, NORLEUCINE, ... 著者 Zhuang, N, Lee, K.H. 登録日 2016-04-26 公開日 2017-05-03 実験手法 X-RAY DIFFRACTION (2.394 Å) 主引用文献 Phenylalanine hydroxylase from dictyostelium - BH2, norleucine complex To Be Published
5JK5	Phenylalanine hydroxylase from dictyostelium - BH2 complex 分子名称: 7,8-DIHYDROBIOPTERIN, FE (III) ION, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), ... 著者 Zhuang, N, Lee, K.H. 登録日 2016-04-26 公開日 2017-04-26 実験手法 X-RAY DIFFRACTION (2.071 Å) 主引用文献 Phenylalanine hydroxylase from dictyostelium - BH2 complex To Be Published

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