4ANP
Crystal structure of human phenylalanine hydroxylase in complex with a pharmacological chaperone
Summary for 4ANP
Entry DOI | 10.2210/pdb4anp/pdb |
Related | 1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4PAH 5PAH 6PAH |
Descriptor | PHENYLALANINE-4-HYDROXYLASE, FE (III) ION, 5,6-DIMETHYL-3-(4-METHYL-2-PYRIDINYL)-2-THIOXO-2,3-DIHYDROTHIENO[2,3- D]PYRIMIDIN-4(1H)-ONE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, phenylketonuria, folding mechanism |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 37903.77 |
Authors | Torreblanca, R.,Lira-Navarrete, E.,Sancho, J.,Hurtado-Guerrero, R. (deposition date: 2012-03-21, release date: 2012-04-11, Last modification date: 2023-12-20) |
Primary citation | Torreblanca, R.,Lira-Navarrete, E.,Sancho, J.,Hurtado-Guerrero, R. Structural and Mechanistic Basis of the Interaction between a Pharmacological Chaperone and Human Phenylalanine Hydroxylase. Chembiochem, 13:1266-, 2012 Cited by PubMed: 22549968DOI: 10.1002/CBIC.201200188 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
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