5J6D
Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors
Summary for 5J6D
| Entry DOI | 10.2210/pdb5j6d/pdb |
| Descriptor | Tryptophan 5-hydroxylase 1, FE (III) ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total) |
| Functional Keywords | tph1, iron, acyl, quanidine, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 72542.12 |
| Authors | Stein, A.J.,Goldberg, D.R.,De Lombaert, S. (deposition date: 2016-04-04, release date: 2016-05-25, Last modification date: 2023-09-27) |
| Primary citation | Goldberg, D.R.,De Lombaert, S.,Aiello, R.,Bourassa, P.,Barucci, N.,Zhang, Q.,Paralkar, V.,Stein, A.J.,Valentine, J.,Zavadoski, W. Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg.Med.Chem.Lett., 26:2855-2860, 2016 Cited by PubMed: 27146606DOI: 10.1016/j.bmcl.2016.04.057 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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