5J6D
Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0009072 | biological_process | aromatic amino acid metabolic process |
A | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0009072 | biological_process | aromatic amino acid metabolic process |
B | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue FE A 501 |
Chain | Residue |
A | HIS272 |
A | HIS277 |
A | GLU317 |
A | TRS502 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue TRS A 502 |
Chain | Residue |
A | FE501 |
A | 6H5504 |
A | HOH606 |
A | HOH621 |
A | HIS272 |
A | GLU273 |
A | HIS277 |
A | TYR312 |
A | GLU317 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | TRP107 |
A | LYS110 |
A | ASP114 |
B | VAL122 |
B | MET124 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue 6H5 A 504 |
Chain | Residue |
A | TYR235 |
A | LEU236 |
A | ARG257 |
A | TYR264 |
A | THR265 |
A | PRO266 |
A | GLU267 |
A | PRO268 |
A | HIS272 |
A | ALA309 |
A | TYR312 |
A | PHE313 |
A | GLU317 |
A | GLY333 |
A | SER336 |
A | SER337 |
A | ILE366 |
A | TRS502 |
A | HOH641 |
A | HOH696 |
B | MET102 |
B | THR104 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue FE B 501 |
Chain | Residue |
B | HIS272 |
B | HIS277 |
B | GLU317 |
B | TRS502 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue TRS B 502 |
Chain | Residue |
B | PHE241 |
B | PRO268 |
B | HIS272 |
B | GLU273 |
B | HIS277 |
B | GLU317 |
B | FE501 |
B | 6H5504 |
B | HOH603 |
B | HOH605 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue GOL B 503 |
Chain | Residue |
A | VAL122 |
A | MET124 |
B | TRP107 |
B | LYS110 |
B | LYS111 |
B | ASP114 |
B | HOH613 |
site_id | AC8 |
Number of Residues | 17 |
Details | binding site for residue 6H5 B 504 |
Chain | Residue |
A | MET102 |
B | LEU129 |
B | TYR235 |
B | LEU236 |
B | ARG257 |
B | TYR264 |
B | THR265 |
B | PRO268 |
B | HIS272 |
B | TYR312 |
B | PHE313 |
B | GLU317 |
B | GLY333 |
B | SER336 |
B | SER337 |
B | ILE366 |
B | TRS502 |
Functional Information from PROSITE/UniProt
site_id | PS00367 |
Number of Residues | 12 |
Details | BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDtcHELLGHVP |
Chain | Residue | Details |
A | PRO268-PRO279 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P70080 |
Chain | Residue | Details |
A | TYR235 | |
B | ILE366 | |
A | ARG257 | |
A | THR265 | |
A | SER336 | |
A | ILE366 | |
B | TYR235 | |
B | ARG257 | |
B | THR265 | |
B | SER336 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12379098, ECO:0007744|PDB:1MLW |
Chain | Residue | Details |
A | HIS272 | |
A | HIS277 | |
A | GLU317 | |
B | HIS272 | |
B | HIS277 | |
B | GLU317 |