3HF6

Crystal structure of human tryptophan hydroxylase type 1 with bound LP-521834 and FE

Summary for 3HF6

Entry DOI	10.2210/pdb3hf6/pdb
Descriptor	Tryptophan 5-hydroxylase 1, FE (III) ION, 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine, ... (4 entities in total)
Functional Keywords	tryptophan 5-hydroxylase 1, alternative splicing, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein, serotonin biosynthesis
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	33772.24
Authors	Tari, L.W.,Swanson, R.V.,Hunter, M.J. (deposition date: 2009-05-11, release date: 2009-11-24, Last modification date: 2024-02-21)
Primary citation	Cianchetta, G.,Stouch, T.,Yu, W.,Shi, Z.-C.,Tari, L.W.,Swanson, R.V.,Hunter, M.J.,Hoffman, I.D.,Liu, Q. Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis Curr Chem Genomics, 4:19-26, 2010 Cited by PubMed: 19631532 DOI: 10.2174/1875397301004010019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation