PDB: 86 件ウェブページステータス検索Chemie searchBIRD

---

3HNE	Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. 登録日 2009-05-31 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3PAW	Low resolution X-ray crystal structure of Yeast Rnr1p with dATP bound in the A-site 分子名称: Ribonucleoside-diphosphate reductase large chain 1 著者 Fairman, J.W, Wijerathna, S.R, Dealwis, C.G. 登録日 2010-10-19 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (6.61 Å) 主引用文献 Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3UUS	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, FE (III) ION, Ribonucleoside-diphosphate reductase 1 subunit alpha, ... 著者 Zimanyi, C.M, Drennan, C.L. 登録日 2011-11-28 公開日 2011-12-21 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (5.65 Å) 主引用文献 Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase. Proc.Natl.Acad.Sci.USA, 108, 2011
3TBA	Structure of Yeast Ribonucleotide Reductase 1 Q288A with dGTP and ADP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C. 登録日 2011-08-05 公開日 2012-04-04 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
3TB9	Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP 分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-08-05 公開日 2012-04-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
3S8B	Structure of Yeast Ribonucleotide Reductase 1 with AMPPNP and CDP 分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8A	Structure of Yeast Ribonucleotide Reductase R293A with dGTP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S87	Structure of Yeast Ribonucleotide Reductase 1 with dGTP and ADP 分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8C	Structure of Yeast Ribonucleotide Reductase 1 R293A with AMPPNP and CDP 分子名称: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. 登録日 2011-05-27 公開日 2012-04-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
4ERP	Crystal structure of a gemcitabine-diphosphate inhibited E. coli class Ia ribonucleotide reductase complex 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MU-OXO-DIIRON, Ribonucleoside-diphosphate reductase 1 subunit alpha, ... 著者 Zimanyi, C.M, Drennan, C.L. 登録日 2012-04-20 公開日 2012-07-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (4.45 Å) 主引用文献 Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure, 20, 2012
4ERM	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex at 4 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Zimanyi, C.M, Drennan, C.L. 登録日 2012-04-20 公開日 2012-07-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.95 Å) 主引用文献 Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase. Structure, 20, 2012
3RSR	Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase 分子名称: 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 著者 Wan, Q, Mohammed, F, Jha, S, Motea, E, Berdis, A, Dealwis, C.G. 登録日 2011-05-02 公開日 2012-11-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Mol.Cancer Ther., 11, 2012
4X3V	Crystal structure of human ribonucleotide reductase 1 bound to inhibitor 分子名称: N~6~-{N-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]-2-methyl-D-alanyl}-D-lysine, Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE 著者 Dealwis, C.G, Ahmad, M.F, Alam, I. 登録日 2014-12-01 公開日 2015-11-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J.Med.Chem., 58, 2015
5CNV	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to GDP and TTP at 3.20 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5CNS	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to CDP and dATP at 2.97 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.975 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5CNT	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to UDP and dATP at 3.25 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, MU-OXO-DIIRON, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5CNU	Crystal structure of the dATP inhibited E. coli class Ia ribonucleotide reductase complex bound to ADP and dGTP at 3.40 Angstroms resolution 分子名称: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Chen, P.Y.-T, Zimanyi, C.M, Funk, M.A, Drennan, C.L. 登録日 2015-07-18 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli. Elife, 5, 2016
5D1Y	Low resolution crystal structure of human ribonucleotide reductase alpha6 hexamer in complex with dATP 分子名称: Ribonucleoside-diphosphate reductase large subunit 著者 Ando, N, Li, H, Brignole, E.J, Thompson, S, McLaughlin, M.I, Page, J, Asturias, F, Stubbe, J, Drennan, C.L. 登録日 2015-08-04 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (9.005 Å) 主引用文献 Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer. Biochemistry, 55, 2016
5IM3	Crystal structure of the class I ribonucleotide reductase from Pseudomonas aeruginosa in complex with dATP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase 著者 Johansson, R, Logan, D.T. 登録日 2016-03-05 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.298 Å) 主引用文献 Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones. Structure, 24, 2016
5TUS	Potent competitive inhibition of human ribonucleotide reductase by a novel non-nucleoside small molecule 分子名称: 2-hydroxy-N'-[(Z)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... 著者 Mohammed, F.A, Alam, I, Dealwis, C.G. 登録日 2016-11-07 公開日 2017-08-02 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6AUI	Human ribonucleotide reductase large subunit (alpha) with dATP and CDP 分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Brignole, E.J, Drennan, C.L, Asturias, F.J, Tsai, K.L, Penczek, P.A. 登録日 2017-09-01 公開日 2018-04-18 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 3.3- angstrom resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife, 7, 2018
6CGM	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit (nucleotide free) 分子名称: 1,2-ETHANEDIOL, Ribonucleoside-diphosphate reductase 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGL	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound as-isolated (pH 4) 分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, Ribonucleoside-diphosphate reductase, SULFATE ION 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CGN	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit dAMP-bound (pH 7) 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ... 著者 Maggiolo, A.O, Boal, A.K. 登録日 2018-02-20 公開日 2018-05-09 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 An endogenous dAMP ligand inBacillus subtilisclass Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6MT9	X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP, ATP, and ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Thomas, W.C, Brooks, F.P, Bacik, J.P, Ando, N. 登録日 2018-10-19 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Convergent allostery in ribonucleotide reductase. Nat Commun, 10, 2019

<1234>