3RSR

Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase

Summary for 3RSR

Entry DOI	10.2210/pdb3rsr/pdb
Related	2CVS 2CVU 2CVV 2CVW 2CVX 2CVY
Descriptor	Ribonucleoside-diphosphate reductase large chain 1, MAGNESIUM ION, 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE, ... (4 entities in total)
Functional Keywords	10-stranded alpha/beta barrel, nucleotide reduction, oxidized, oxidoreductase
Biological source	Saccharomyces cerevisiae (yeast)
Cellular location	Cytoplasm: P21524
Total number of polymer chains	1
Total formula weight	100215.49
Authors	Wan, Q.,Mohammed, F.,Jha, S.,Motea, E.,Berdis, A.,Dealwis, C.G. (deposition date: 2011-05-02, release date: 2012-11-14)
Primary citation	Ahmad, M.F.,Wan, Q.,Jha, S.,Motea, E.,Berdis, A.,Dealwis, C. Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Mol.Cancer Ther., 11:2077-2086, 2012 Cited by PubMed: 22933704 DOI: 10.1158/1535-7163.MCT-12-0199 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation