8RTY
| Structure of the F-actin barbed end bound by Cdc12 and profilin (ring complex) at a resolution of 6.3 Angstrom | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | Deposit date: | 2024-01-29 | Release date: | 2024-04-10 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (6.25 Å) | Cite: | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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8C47
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8BR0
| ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin (residue Q3455 to L3863) in complex with 3'deoxyCTP and two manganese cations bound to Latrunculin-B-ADP-Mn-actin | Descriptor: | 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Texeira-Nuns, M, Retailleau, P, Renault, L. | Deposit date: | 2022-11-22 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.218 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJI
| chimera of ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo fused to a proline-Rich-Domain (PRD) and profilin, bound to ADP-Mg-actin and a sulfate ion | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJH
| chimera of the inactive ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, with the double mutation K3528M and K3535I, fused to a proline-Rich-Domain (PRD) and profilin, bound to Latrunculin B-ADP-Mg-actin | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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8BJJ
| ExoY Nucleotidyl Cyclase domain from Vibrio nigripulchritudo MARTX toxin, bound to ATP-Mg-actin, human profilin 1 and a sulfate ion | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Teixeira-Nunes, M, Renault, L, Retailleau, P. | Deposit date: | 2022-11-04 | Release date: | 2023-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin. Plos Pathog., 19, 2023
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7SBD
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7SBG
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7PBH
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7P1H
| Structure of the V. vulnificus ExoY-G-actin-profilin complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Belyy, A, Merino, F, Raunser, S. | Deposit date: | 2021-07-01 | Release date: | 2021-11-17 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens. Nat Commun, 12, 2021
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7KYW
| Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer | Descriptor: | CITRIC ACID, Profilin-1 | Authors: | O'Malley, A, Kapingidza, A.B, Hyduke, N, Dolamore, C, Chruszcz, M. | Deposit date: | 2020-12-09 | Release date: | 2021-03-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer. Acta Biochim.Pol., 68, 2021
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6NBW
| Ternary Complex of Beta/Gamma-Actin with Profilin and AnCoA-NAA80 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | Deposit date: | 2018-12-10 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanism of actin N-terminal acetylation. Sci Adv, 6, 2020
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6NBE
| Ternary Complex of Ac-Alpha-Actin with Profilin and CoA-NAA80 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | Deposit date: | 2018-12-07 | Release date: | 2020-04-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanism of actin N-terminal acetylation. Sci Adv, 6, 2020
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6NAS
| Ternary Complex of Ac-Alpha-Actin with Profilin and AcCoA-NAA80 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Rebowski, G, Boczkowska, M, Dominguez, R. | Deposit date: | 2018-12-06 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Mechanism of actin N-terminal acetylation. Sci Adv, 6, 2020
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6IQI
| crystal structure of Arabidopsis thaliana Profilin 2 | Descriptor: | Profilin-2 | Authors: | Qiao, Z, Gao, Y. | Deposit date: | 2018-11-08 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and computational examination of theArabidopsisprofilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly. J.Biol.Chem., 294, 2019
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6IQK
| crystal structure of Arabidopsis thaliana Profilin 3 | Descriptor: | AtPRF3, Profilin-5 | Authors: | Qiao, Z, Gao, Y. | Deposit date: | 2018-11-08 | Release date: | 2019-11-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structural and computational examination of theArabidopsisprofilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly. J.Biol.Chem., 294, 2019
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6IQJ
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6IQF
| crystal structure of Arabidopsis thaliana Profilin 3 | Descriptor: | PRF3 | Authors: | Qiao, Z, Gao, Y. | Deposit date: | 2018-11-07 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.457 Å) | Cite: | Structural and computational examination of theArabidopsisprofilin-Poly-P complex reveals mechanistic details in profilin-regulated actin assembly. J.Biol.Chem., 294, 2019
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6MBX
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5ZZB
| LokiProfilin2/Rabbit Actin Complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Robinson, R.C, Akil, C. | Deposit date: | 2018-05-31 | Release date: | 2018-10-10 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Genomes of Asgard archaea encode profilins that regulate actin. Nature, 562, 2018
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6B6J
| Structure of profilin Art v4 | Descriptor: | Profilin-1 | Authors: | Pye, S.E, Pote, S.S, Chruszcz, M. | Deposit date: | 2017-10-02 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Comparative structural and thermal stability studies of Cuc m 2.0101, Art v 4.0101 and other allergenic profilins. Mol.Immunol., 114, 2019
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5YEE
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5YED
| Crystal structure of LokiProfilin1 | Descriptor: | Uncharacterized protein | Authors: | Robinson, R.C, Akil, C. | Deposit date: | 2017-09-16 | Release date: | 2018-09-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Genomes of Asgard archaea encode profilins that regulate actin. Nature, 562, 2018
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5NZC
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5NZB
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