4MMD
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4US4
| Crystal Structure of the Bacterial NSS Member MhsT in an Occluded Inward-Facing State (lipidic cubic phase form) | Descriptor: | (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, SODIUM ION, ... | Authors: | Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P. | Deposit date: | 2014-07-02 | Release date: | 2014-09-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters Nat.Struct.Mol.Biol., 21, 2014
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4US3
| Crystal Structure of the bacterial NSS member MhsT in an Occluded Inward-Facing State | Descriptor: | DODECYL-ALPHA-D-MALTOSIDE, SODIUM ION, TRANSPORTER, ... | Authors: | Malinauskaite, L, Quick, M, Reinhard, L, Lyons, J.A, Yano, H, Javitch, J.A, Nissen, P. | Deposit date: | 2014-07-02 | Release date: | 2014-09-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | A Mechanism for Intracellular Release of Na+ by Neurotransmitter/Sodium Symporters Nat.Struct.Mol.Biol., 21, 2014
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4XP4
| X-ray structure of Drosophila dopamine transporter in complex with cocaine | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XNU
| X-ray structure of Drosophila dopamine transporter in complex with nisoxetine | Descriptor: | CHLORIDE ION, CHOLESTEROL, Integral membrane protein-dopamine transporter, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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4XPF
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to RTI-55 | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ANTIBODY FRAGMENT HEAVY CHAIN-PROTEIN, 9D5-HEAVY CHAIN, ... | Authors: | Penmatsa, A, Wang, K.H, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.273 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPG
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to beta-CFT or Win35428 | Descriptor: | CHLORIDE ION, CHOLESTEROL, Dopamine transporter, ... | Authors: | Penmatsa, A, Wang, K.H, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP1
| X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine | Descriptor: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP5
| X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55 | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Antibody fragment heavy chain-protein, 9D5-heavy chain, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPB
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine | Descriptor: | Antibody fragment heavy chain-protein, 9D5-heavy chain, Antibody fragment light chain-protein, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XNX
| X-ray structure of Drosophila dopamine transporter in complex with reboxetine | Descriptor: | (2R)-2-[(R)-(2-ethoxyphenoxy)(phenyl)methyl]morpholine, Antibody fragment heavy chain, CHLORIDE ION, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine. Nat.Struct.Mol.Biol., 22, 2015
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4XP6
| X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine | Descriptor: | (2S)-N-methyl-1-phenylpropan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody fragment heavy chain-protein, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XP9
| X-ray structure of Drosophila dopamine transporter bound to psychostimulant D-amphetamine | Descriptor: | (2S)-1-phenylpropan-2-amine, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPA
| X-ray structure of Drosophila dopamine transporter bound to 3,4dichlorophenethylamine | Descriptor: | 2-(3,4-dichlorophenyl)ethanamine, Antibody fragment heavy chain-protein, 9D5-heavy chain, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-16 | Release date: | 2015-05-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPT
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations D121G/S426M and EL2 deletion of 162-201 in complex with substrate analogue 3,4 dichlorophen ethylamine | Descriptor: | 2-(3,4-dichlorophenyl)ethanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Aravind, P, Wang, K, Gouaux, E. | Deposit date: | 2015-01-17 | Release date: | 2015-05-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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4XPH
| X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to 3,4dichlorophenethylamine | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-(3,4-dichlorophenyl)ethanamine, Antibody fragment heavy chain, ... | Authors: | Penmatsa, A, Wang, K, Gouaux, E. | Deposit date: | 2015-01-17 | Release date: | 2015-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Neurotransmitter and psychostimulant recognition by the dopamine transporter. Nature, 521, 2015
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5I74
| X-ray structure of the ts3 human serotonin transporter complexed with Br-citalopram at the central site | Descriptor: | (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, ... | Authors: | Coleman, J.A, Green, E.M, Gouaux, E. | Deposit date: | 2016-02-16 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.395 Å) | Cite: | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
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5I71
| X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site | Descriptor: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, ... | Authors: | Coleman, J.A, Green, E.M, Gouaux, E. | Deposit date: | 2016-02-16 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
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5I6X
| X-ray structure of the ts3 human serotonin transporter complexed with paroxetine at the central site | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | Authors: | Coleman, J.A, Green, E.M, Gouaux, E. | Deposit date: | 2016-02-16 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
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5I73
| X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central and allosteric sites | Descriptor: | (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINOHEXANOIC ACID, ... | Authors: | Coleman, J.A, Green, E.M, Gouaux, E. | Deposit date: | 2016-02-16 | Release date: | 2016-04-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
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5I6Z
| X-ray structure of the ts2 human serotonin transporter | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8B6 antibody, heavy chain, ... | Authors: | Coleman, J.A, Green, E.M, Gouaux, E. | Deposit date: | 2016-02-16 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.53 Å) | Cite: | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
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5I75
| X-ray structure of the ts3 human serotonin transporter complexed with s-citalopram at the central site and Br-citalopram at the allosteric site | Descriptor: | (1S)-1-(4-bromophenyl)-1-[3-(dimethylamino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile, (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Coleman, J.A, Green, E.M, Gouaux, E. | Deposit date: | 2016-02-16 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.49 Å) | Cite: | X-ray structures and mechanism of the human serotonin transporter. Nature, 532, 2016
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5JAE
| LeuT in the outward-oriented, Na+-free return state, P21 form at pH 6.5 | Descriptor: | Transporter, octyl beta-D-glucopyranoside | Authors: | Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P. | Deposit date: | 2016-04-12 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nat Commun, 7, 2016
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5JAF
| LeuT Na+-free Return State, C2 form at pH 5 | Descriptor: | Transporter, octyl beta-D-glucopyranoside | Authors: | Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P. | Deposit date: | 2016-04-12 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.021 Å) | Cite: | A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nat Commun, 7, 2016
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5JAG
| LeuT T354H mutant in the outward-oriented, Na+-free Return State | Descriptor: | Transporter, octyl beta-D-glucopyranoside | Authors: | Malinauskaite, L, Sahin, C, Said, S, Grouleff, J, Shahsavar, A, Bjerregaard, H, Noer, P, Severinsen, K, Boesen, T, Schiott, B, Sinning, S, Nissen, P. | Deposit date: | 2016-04-12 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | A conserved leucine occupies the empty substrate site of LeuT in the Na(+)-free return state. Nat Commun, 7, 2016
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