PDB: 614 件ウェブページステータス検索Chemie searchBIRD

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5Z6K	High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 400 MPa 分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Watanabe, N, Nagae, T, Yamada, H. 登録日 2018-01-23 公開日 2018-09-19 実験手法 X-RAY DIFFRACTION (1.802 Å) 主引用文献 High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP. Acta Crystallogr D Struct Biol, 74, 2018
5Z6J	High-pressure Crystal Structure Analysis of M20 loop closed DHFR at 220 MPa 分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Watanabe, N, Nagae, T, Yamada, H. 登録日 2018-01-23 公開日 2018-09-19 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP. Acta Crystallogr D Struct Biol, 74, 2018
5Z6F	High-pressure Crystal Structure Analysis of DHFR(0.1 MPa) 分子名称: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Watanabe, N, Nagae, T, Yamada, H. 登録日 2018-01-22 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP. Acta Crystallogr D Struct Biol, 74, 2018
5W3Q	L28F E.coli DHFR in complex with NADPH 分子名称: CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Oyen, D, Wright, P.E, Wilson, I.A. 登録日 2017-06-08 公開日 2017-08-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.401 Å) 主引用文献 Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
5UJX	Crystal structure of DHFR in 20% Isopropanol 分子名称: CALCIUM ION, CHLORIDE ION, Dihydrofolate reductase, ... 著者 Cuneo, M.J, Agarwal, P.K. 登録日 2017-01-19 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Modulating Enzyme Activity by Altering Protein Dynamics with Solvent. Biochemistry, 57, 2018
5UJF	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor 分子名称: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-01-17 公開日 2017-02-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound p218 Inhibitor TO BE PUBLISHED
5UIP	structure of DHFR with bound DAP, p-ABG and NADP 分子名称: Dihydrofolate reductase, N-(4-aminobenzene-1-carbonyl)-L-glutamic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Pedersen, L.C, London, R.E. 登録日 2017-01-14 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5UIO	structure of DHFR with bound DAP, p-ABG and NADP 分子名称: BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FORMIC ACID, ... 著者 Pedersen, L.C, London, R.E. 登録日 2017-01-14 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.929 Å) 主引用文献 A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5UII	structure of DHFR with bound buformin and NADP 分子名称: CALCIUM ION, Dihydrofolate reductase, N-butyl-N'-(diaminomethylidene)guanidine, ... 著者 Pedersen, L.C, London, R.E. 登録日 2017-01-14 公開日 2018-01-31 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.351 Å) 主引用文献 A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5UIH	structure of DHFR with bound phenformin and NADP 分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Dihydrofolate reductase, ... 著者 Pedersen, L.C, London, R.E. 登録日 2017-01-14 公開日 2017-11-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.647 Å) 主引用文献 A Structural Basis for Biguanide Activity. Biochemistry, 56, 2017
5U27	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor 分子名称: 1,2-ETHANEDIOL, 2,4-diamino-6-methyl-5-[3-(2,4,5-trichlorophenoxy)propyloxy]pyrimidine, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-11-29 公開日 2016-12-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p65 Inhibitor TO BE PUBLISHED
5U26	Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor 分子名称: 1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2016-11-29 公開日 2016-12-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of Mycobacterium tuberculosis Dihydrofolate Reductase Bound to NADP and p218 Inhibitor TO BE PUBLISHED
5T7O	Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE 分子名称: (6S)-5,6,7,8-TETRAHYDROFOLATE, 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... 著者 Di Pisa, F, Dello Iacono, L, Bonucci, A, Mangani, S. 登録日 2016-09-05 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase in complex with (6S)-5,6,7,8-TETRAHYDROFOLATE To Be Published
5T0L	Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15) 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-[4-(3,4-dichlorophenyl)piperazin-1-yl]pyrimidine-2,4-diamine, ... 著者 Thomas, S.B, Chen, Z, Lu, H, Li, Y. 登録日 2016-08-16 公開日 2016-09-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.13 Å) 主引用文献 Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. ACS Med Chem Lett, 7, 2016
5SSW	DHFR:NADP+:FOL complex at 270 K (multi-crystal) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-07-03 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 DHFR:NADP+:FOL complex at 270 K To Be Published
5SSV	DHFR:NADP+:FOL complex at 270 K (crystal 4) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-07-03 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.08 Å) 主引用文献 DHFR:NADP+:FOL complex at 270 K To Be Published
5SSU	DHFR:NADP+:FOL complex at 270 K (crystal 3) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-07-03 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 DHFR:NADP+:FOL complex at 270 K To Be Published
5SST	DHFR:NADP+:FOL complex at 270 K (crystal 2) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-07-03 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.07 Å) 主引用文献 DHFR:NADP+:FOL complex at 270 K To Be Published
5SSS	DHFR:NADP+:FOL complex at 270 K (crystal 1) 分子名称: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... 著者 Greisman, J.B, Dalton, K.M, Brookner, D.E, Hekstra, D.R. 登録日 2022-07-03 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 DHFR:NADP+:FOL complex at 270 K To Be Published
5SDB	Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate 分子名称: 1,2-ETHANEDIOL, Dihydrofolate reductase, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2022-03-02 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate to be published
5SDA	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774 分子名称: (2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2022-03-02 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774 to be published
5SD9	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096 分子名称: (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3-fluoropropanoic acid, 1,2-ETHANEDIOL, Dihydrofolate reductase, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2022-03-02 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1096 to be published
5SD8	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture) 分子名称: (2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2022-03-02 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture) to be published
5SD7	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735 分子名称: (2S)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2022-03-02 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-735 to be published
5SD6	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892 分子名称: 1,2-ETHANEDIOL, 6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2021-12-20 公開日 2022-02-09 最終更新日 2022-03-02 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-892 to be published

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