5SDB

Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate

Summary for 5SDB

• Entry DOI: 10.2210/pdb5sdb/pdb
• Group deposition: DHFR structures, SSGCID (G_1002223)
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ... (5 entities in total)
• Functional Keywords: structure-guided drug discovery consortium, dihydrofolate reductase, hdhfr, nadp, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 45575.34

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-12-20, release date: 2022-02-09, Last modification date: 2022-03-02)

• Primary citation: Mayclin, S.J.,Fairman, J.W.,Dranow, D.M.,Conrady, D.G.,Fox III, D.,Lukacs, C.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Abendroth, J.; Crystal Structure of Human DHFR complexed with NADP and N10-formyl-tetrahydrofolate; to be published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)