PDB: 394 件ウェブページステータス検索Chemie searchBIRD

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6SQR	Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ... 著者 Magnussen, H.M, Ahmed, S.F, Huang, D.T. 登録日 2019-09-04 公開日 2020-05-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nat Commun, 11, 2020
4P5O	Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate intermediate trapped in action 分子名称: Cullin-1, DCN1-like protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Scott, D.C, Schulman, B.A. 登録日 2014-03-18 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.1071 Å) 主引用文献 Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8. Cell, 157, 2014
4Q5H	Shigella Effector Kinase OspG bound to AMPPNP and E2-Ub UbcH7-Ub Conjugate 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Polyubiquitin, ... 著者 Cygler, M, Grishin, A.M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) 登録日 2014-04-16 公開日 2014-07-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG. Structure, 22, 2014
6T7F	RCR E3 ligase E2-Ubiquitin transthiolation intermediate 分子名称: 3,3-bis(sulfanyl)-~{N}-(1~{H}-1,2,3-triazol-4-ylmethyl)propanamide, E3 ubiquitin-protein ligase MYCBP2, Polyubiquitin-C, ... 著者 Mabbitt, P.D, Virdee, S. 登録日 2019-10-21 公開日 2020-08-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nat.Chem.Biol., 16, 2020
8ATU	Cryo-EM structure of human BIRC6 分子名称: Baculoviral IAP repeat-containing protein 6, ZINC ION 著者 Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. 登録日 2022-08-24 公開日 2023-02-15 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
8AUK	Cryo-EM structure of human BIRC6 in complex with HTRA2. 分子名称: Baculoviral IAP repeat-containing protein 6, Serine protease HTRA2, mitochondrial, ... 著者 Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. 登録日 2022-08-25 公開日 2023-02-15 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (6.2 Å) 主引用文献 Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
8AUW	Cryo-EM structure of human BIRC6 in complex with SMAC. 分子名称: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein, ZINC ION 著者 Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. 登録日 2022-08-25 公開日 2023-02-15 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (7.2 Å) 主引用文献 Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
8ATX	Cryo-EM structure of human BIRC6 - no substrate 分子名称: Baculoviral IAP repeat-containing protein 6, ZINC ION 著者 Ehrmann, J.F, Grabarczyk, D.B, Clausen, T. 登録日 2022-08-24 公開日 2023-02-15 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex. Science, 379, 2023
4Q5E	Shigella Effector Kinase OspG bound to E2-Ub UbcH7-Ub Conjugate 分子名称: Polyubiquitin, Protein kinase OspG, Ubiquitin-conjugating enzyme E2 L3 著者 Cygler, M, Grishin, A.M, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) 登録日 2014-04-16 公開日 2014-07-02 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (1.869 Å) 主引用文献 Structural Basis for the Inhibition of Host Protein Ubiquitination by Shigella Effector Kinase OspG. Structure, 22, 2014
8ATO	Structure of the giant inhibitor of apoptosis, BIRC6 bound to the regulator SMAC 分子名称: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein 著者 Dietz, L, Elliott, P.R. 登録日 2022-08-23 公開日 2023-03-08 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379, 2023
8ATM	Structure of the giant inhibitor of apoptosis, BIRC6 (composite map) 分子名称: Baculoviral IAP repeat-containing protein 6 著者 Dietz, L, Elliott, P.R. 登録日 2022-08-23 公開日 2023-03-08 最終更新日 2023-03-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6. Science, 379, 2023
6TTU	Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2 分子名称: CYS-LYS-LYS-ALA-ARG-HIS-ASP-SEP-GLY, Cullin-1, E3 ubiquitin-protein ligase RBX1, ... 著者 Baek, K, Prabu, J.R, Schulman, B.A. 登録日 2019-12-30 公開日 2020-02-12 最終更新日 2020-03-04 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly. Nature, 578, 2020
8B3I	CRL4CSA-E2-Ub (state 2) 分子名称: Cullin-4A, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... 著者 Kokic, G, Cramer, P. 登録日 2022-09-16 公開日 2023-09-27 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 C(N)RL4CSA-E2-Ub (state 2) To Be Published
8AMS	Complex of human TRIM2 RING domain, UBCH5C, and Ubiquitin 分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Polyubiquitin-C, ... 著者 Perez-Borrajero, C, Kotova, I, Murciano, B, Hennig, J. 登録日 2022-08-04 公開日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and biophysical studies of TRIM2 and TRIM3 To Be Published
4QPL	Crystal structure of RNF146(RING-WWE)/UbcH5a/iso-ADPr complex 分子名称: 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), E3 ubiquitin-protein ligase RNF146, Ubiquitin-conjugating enzyme E2 D1, ... 著者 Wang, Z, DaRosa, P.A, Klevit, R.E, Xu, W. 登録日 2014-06-23 公開日 2014-10-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature, 517, 2015
6ULH	Structure of MavC in complex with its substrate in R3 spacegroup 分子名称: LPG2147 (MavC), Ubiquitin, Ubiquitin-conjugating enzyme E2 N 著者 Iyer, S, Puvar, K, Das, C. 登録日 2019-10-08 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.968 Å) 主引用文献 Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. Nat Commun, 11, 2020
6UMS	Crystal structure of MavC in complex with its substrate mimic in C222(1) space group 分子名称: MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N 著者 Iyer, S, Puvar, K, Das, C. 登録日 2019-10-10 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.344 Å) 主引用文献 Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. Nat Commun, 11, 2020
4R62	Structure of Rad6~Ub 分子名称: ACETATE ION, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 2 著者 Kumar, P, Wolberger, C. 登録日 2014-08-22 公開日 2015-09-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Role of a non-canonical surface of Rad6 in ubiquitin conjugating activity. Nucleic Acids Res., 43, 2015
6UMP	Crystal structure of MavC in complex with substrate mimic in P65 space group 分子名称: MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N 著者 Puvar, K, Iyer, S, Luo, Z.Q, Das, C. 登録日 2019-10-10 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. Nat Commun, 11, 2020
2LXP	NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its conjugating enzyme Ube2g 分子名称: E3 ubiquitin-protein ligase AMFR, Ubiquitin-conjugating enzyme E2 G2, ZINC ION 著者 Das, R, Linag, Y, Mariano, J, Li, J, Huang, T, King, A, Weissman, A, Ji, X, Byrd, R. 登録日 2012-08-30 公開日 2013-08-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine. Embo J., 32, 2013
4AP4	Rnf4 - ubch5a - ubiquitin heterotrimeric complex 分子名称: E3 UBIQUITIN LIGASE RNF4, UBIQUITIN C, UBIQUITIN-CONJUGATING ENZYME E2 D1, ... 著者 Plechanovova, A, Hay, R.T, Tatham, M.H, Jaffray, E, Naismith, J.H. 登録日 2012-03-30 公開日 2012-07-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Structure of a Ring E3 Ligase and Ubiquitin-Loaded E2 Primed for Catalysis Nature, 489, 2012
8BTL	Crystal structure of a complex between the E2 conjugating enzyme UBE2A and the E3 ligase module from UBR4 分子名称: Ubiquitin conjugating enzyme E2 A, ZINC ION, cDNA FLJ12511 fis, ... 著者 Virdee, S, Mabbitt, P.D, Barnsby-Greer, L. 登録日 2022-11-29 公開日 2023-12-13 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4. Nat.Struct.Mol.Biol., 31, 2024
4TKP	Complex of Ubc13 with the RING domain of the TRIM5alpha retroviral restriction factor 分子名称: SULFATE ION, Tripartite motif-containing protein 5, Ubiquitin-conjugating enzyme E2 N, ... 著者 Johnson, R, Taylor, A.B, Hart, P.J, Ivanov, D.N. 登録日 2014-05-27 公開日 2015-07-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 RING Dimerization Links Higher-Order Assembly of TRIM5 alpha to Synthesis of K63-Linked Polyubiquitin. Cell Rep, 12, 2015
4S3O	PCGF5-RING1B-UbcH5c complex 分子名称: E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ... 著者 Taherbhoy, A.M, Cochran, A.G. 登録日 2015-03-23 公開日 2015-07-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Nat Commun, 6, 2015
4AUQ	Structure of BIRC7-UbcH5b-Ub complex. 分子名称: BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7, POLYUBIQUITIN-C, UBIQUITIN-CONJUGATING ENZYME E2 D2, ... 著者 Dou, H, Buetow, L, Sibbet, G.J, Cameron, K, Huang, D.T. 登録日 2012-05-21 公開日 2012-08-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.176 Å) 主引用文献 Birc7-E2 Ubiquitin Conjugate Structure Reveals the Mechanism of Ubiquitin Transfer by a Ring Dimer. Nat.Struct.Mol.Biol., 19, 2012

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