4QPL

Crystal structure of RNF146(RING-WWE)/UbcH5a/iso-ADPr complex

Summary for 4QPL

Entry DOI	10.2210/pdb4qpl/pdb
Descriptor	E3 ubiquitin-protein ligase RNF146, Ubiquitin-conjugating enzyme E2 D1, 2'-O-(5-O-phosphono-alpha-D-ribofuranosyl)adenosine 5'-(dihydrogen phosphate), ... (5 entities in total)
Functional Keywords	protein poly(adp-ribosy)lation, ubiquitination, e2/e3 ubiquitin ligase, wnt signaling, rnf146, ubch5a, iso-adpr, ligase
Biological source	Mus musculus (mouse) More
Cellular location	Cytoplasm, cytosol : Q9CZW6 Cytoplasm : P51668
Total number of polymer chains	4
Total formula weight	72139.37
Authors	Wang, Z.,DaRosa, P.A.,Klevit, R.E.,Xu, W. (deposition date: 2014-06-23, release date: 2014-10-15, Last modification date: 2024-02-28)
Primary citation	DaRosa, P.A.,Wang, Z.,Jiang, X.,Pruneda, J.N.,Cong, F.,Klevit, R.E.,Xu, W. Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. Nature, 517:223-226, 2015 Cited by PubMed: 25327252 DOI: 10.1038/nature13826 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation